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Target
Caspase-2
Ligand
BDBM50376460
Substrate
n/a
Meas. Tech.
ChEMBL_476696 (CHEMBL933486)
EC50
25000±n/a nM
Citation
 Goode, DR; Totten, RK; Heeres, JT; Hergenrother, PJ Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. J Med Chem 51:2346-9 (2008) [PubMed]  Article 
Target
Name:
Caspase-2
Synonyms:
Caspase-2 subunit p18 | Neural precursor cell expressed developmentally down-regulated protein 2 | ICH-1L/1S | ICH-1 protease | Caspase-2 subunit p12 | Caspase-2 subunit p13 | NEDD-2 | CASP-2 | CASP2_HUMAN | CASP2 | ICH1 | NEDD2
Type:
Enzyme
Mol. Mass.:
50688.29
Organism:
Human
Description:
P42575
Residue:
452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
  
Inhibitor
Name:
BDBM50376460
Synonyms:
CHEMBL411858
Type:
Small organic molecule
Emp. Form.:
C25 H37 N O2
Mol. Mass.:
n/a
SMILES:
CC1CCCN(CC(O)COc2ccc(cc2)C23CC4CC(CC(C4)C2)C3)C1 |w:7.7,1.0,TLB:14:17:20:24.23.22,THB:18:19:22:26.17.25,18:17:20.19.24:22,25:17:20:24.23.22,25:23:20:26.18.17|
Structure:
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