Reaction Details Report a problem with these data
Target
Caspase-2
Ligand
BDBM50376461
Substrate
n/a
Meas. Tech.
ChEMBL_476696 (CHEMBL933486)
EC50
50000±n/a nM
Citation
 Goode, DR; Totten, RK; Heeres, JT; Hergenrother, PJ Identification of promiscuous small molecule activators in high-throughput enzyme activation screens. J Med Chem 51:2346-9 (2008) [PubMed]  Article 
Target
Name:
Caspase-2
Synonyms:
Caspase-2 subunit p18 | Neural precursor cell expressed developmentally down-regulated protein 2 | ICH-1L/1S | ICH-1 protease | Caspase-2 subunit p12 | Caspase-2 subunit p13 | NEDD-2 | CASP-2 | CASP2_HUMAN | CASP2 | ICH1 | NEDD2
Type:
Enzyme
Mol. Mass.:
50688.29
Organism:
Human
Description:
P42575
Residue:
452
Sequence:
MAAPSAGSWSTFQHKELMAADRGRRILGVCGMHPHHQETLKKNRVVLAKQLLLSELLEHLLEKDIITLEMRELIQAKVGSFSQNVELLNLLPKRGPQAFDAFCEALRETKQGHLEDMLLTTLSGLQHVLPPLSCDYDLSLPFPVCESCPLYKKLRLSTDTVEHSLDNKDGPVCLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGGDVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIVALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRGDETDRGVDQQDGKNHAGSPGCEESDAGKEKLPKMRLPTRSDMICGYACLKGTAAMRNTKRGSWYIEALAQVFSERACDMHVADMLVKVNALIKDREGYAPGTEFHRCKEMSEYCSTLCRHLYLFPGHPPT
  
Inhibitor
Name:
BDBM50376461
Synonyms:
CHEMBL262596
Type:
Small organic molecule
Emp. Form.:
C26 H25 N3 O
Mol. Mass.:
n/a
SMILES:
Cc1cc(NNC(=O)C(c2ccccc2)c2ccccc2)c2ccc(C)c(C)c2n1
Structure:
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