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Target
CAAX prenyl protease 1 homolog
Ligand
BDBM578
Substrate
n/a
Meas. Tech.
ChEMBL_476919 (CHEMBL924570)
IC50
18400±n/a nM
Citation
 Coffinier, C; Hudon, SE; Farber, EA; Chang, SY; Hrycyna, CA; Young, SG; Fong, LG HIV protease inhibitors block the zinc metalloproteinase ZMPSTE24 and lead to an accumulation of prelamin A in cells. Proc Natl Acad Sci U S A 104:13432-7 (2007) [PubMed]  Article 
Target
Name:
CAAX prenyl protease 1 homolog
Synonyms:
FACE-1 | FACE1_MOUSE | Face1 | Farnesylated proteins-converting enzyme 1 | Prenyl protein-specific endoprotease 1 | Zinc metalloproteinase Ste24 homolog | Zmpste24
Type:
PROTEIN
Mol. Mass.:
54735.85
Organism:
Mus musculus
Description:
ChEMBL_476919
Residue:
475
Sequence:
MGMWASVDAMWDFPAEKRIFGAVLLFSWTVYLWETFLAQRQRRIYKTTTRVPAELEQIMDSDTFEKSRLYQLDKSTFSFWSGLYSEVEGTFILLFGGIPYLWRLSGQFCSSAGFGPEYEIIQSLVFLLLATLFSALTGLPWSLYNTFVIEEKHGFNHQTLEFFMKDAIKKFIVTQCILLPVSALLLYIIKIGGDYFFIYAWLFTLVVSLVLVTIYADYIAPLFDKFTPLPEGKLKQEIEVMAKSIDFPLTKVYVVEGSKRSSHSNAYFYGFFKNKRIVLFDTLLEEYSVPNKDNQEESGMEARNEGEGDSEEVKAKVKNKKQGCKNEEVLAVLGHELGHWKLGHTVKNIIISQMNSFLCFFLFAVLIGRRELFAAFGFYDSQPTLIGLLIIFQFIFSPYNEVLSFCLTVLSRRFEFQADAFAKKLGKAKDLYSALIKLNKDNLGFPVSDWLFSTWHYSHPPLLERLQALKNAKQD
  
Inhibitor
Name:
BDBM578
Synonyms:
(2S)-N-[(2S,4S,5S)-5-[2-(2,6-dimethylphenoxy)acetamido]-4-hydroxy-1,6-diphenylhexan-2-yl]-3-methyl-2-(2-oxo-1,3-diazinan-1-yl)butanamide | ABT-378 | Aluviran | CHEMBL729 | LPV | Lopinavir
Type:
Small organic molecule
Emp. Form.:
C37H48N4O5
Mol. Mass.:
628.8008
SMILES:
CC(C)[C@H](N1CCCNC1=O)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)COc1c(C)cccc1C)Cc1ccccc1 |r|
Structure:
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