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Target
Adenosylhomocysteinase
Ligand
BDBM50135288
Substrate
n/a
Meas. Tech.
ChEMBL_476996 (CHEMBL937500)
IC50
3100±n/a nM
Citation
 Ando, T; Kojima, K; Chahota, P; Kozaki, A; Milind, ND; Kitade, Y Synthesis of 4'-modified noraristeromycins to clarify the effect of the 4'-hydroxyl groups for inhibitory activity against S-adenosyl-L-homocysteine hydrolase. Bioorg Med Chem Lett 18:2615-8 (2008) [PubMed]  Article 
Target
Name:
Adenosylhomocysteinase
Synonyms:
Adenosylhomocysteinase | SAHH_HUMAN | AHCY | SAHH
Type:
PROTEIN
Mol. Mass.:
47714.06
Organism:
Human
Description:
ChEMBL_1507791
Residue:
432
Sequence:
MSDKLPYKVADIGLAAWGRKALDIAENEMPGLMRMRERYSASKPLKGARIAGCLHMTVETAVLIETLVTLGAEVQWSSCNIFSTQDHAAAAIAKAGIPVYAWKGETDEEYLWCIEQTLYFKDGPLNMILDDGGDLTNLIHTKYPQLLPGIRGISEETTTGVHNLYKMMANGILKVPAINVNDSVTKSKFDNLYGCRESLIDGIKRATDVMIAGKVAVVAGYGDVGKGCAQALRGFGARVIITEIDPINALQAAMEGYEVTTMDEACQEGNIFVTTTGCIDIILGRHFEQMKDDAIVCNIGHFDVEIDVKWLNENAVEKVNIKPQVDRYRLKNGRRIILLAEGRLVNLGCAMGHPSFVMSNSFTNQVMAQIELWTHPDKYPVGVHFLPKKLDEAVAEAHLGKLNVKLTKLTEKQAQYLGMSCDGPFKPDHYRY
  
Inhibitor
Name:
BDBM50135288
Synonyms:
CHEMBL129014 | (1S,2R,3S,4R)-4-(6-amino-9H-purin-9-yl)cyclopentane-1,2,3-triol | (1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-cyclopentane-1,2,3-triol | NORARISTEROMYCIN
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1nc(c2c(n1)n(cn2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)O)N
Structure:
Search PDB for entries with ligand similarity: