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Target
Disintegrin and metalloproteinase domain-containing protein 17
Ligand
BDBM50247704
Substrate
n/a
Meas. Tech.
ChEMBL_495052 (CHEMBL1003624)
IC50
28±n/a nM
Citation
 DasGupta, S; Murumkar, PR; Giridhar, R; Yadav, MR Current perspective of TACE inhibitors: a review. Bioorg Med Chem 17:444-59 (2009) [PubMed]  Article 
Target
Name:
Disintegrin and metalloproteinase domain-containing protein 17
Synonyms:
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) | Disintegrin and metalloproteinase domain-containing protein 17 (ADAM-17) | TNF-alpha convertase | TNF-alpha converting enzyme (TACE) | TNF-alpha-converting enzyme (TACE) | Tumor Necrosis Factor Alpha Converting Enzyme | Tumor necrosis factor-+- converting enzyme (TACE) | ADA17_HUMAN | ADAM17 | CSVP | TACE
Type:
Enzyme
Mol. Mass.:
93007.89
Organism:
Human
Description:
Residue:
824
Sequence:
MRQSLLFLTSVVPFVLAPRPPDDPGFGPHQRLEKLDSLLSDYDILSLSNIQQHSVRKRDLQTSTHVETLLTFSALKRHFKLYLTSSTERFSQNFKVVVVDGKNESEYTVKWQDFFTGHVVGEPDSRVLAHIRDDDVIIRINTDGAEYNIEPLWRFVNDTKDKRMLVYKSEDIKNVSRLQSPKVCGYLKVDNEELLPKGLVDREPPEELVHRVKRRADPDPMKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTSWDNAGFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQFSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYYSPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGLAECAPNEDQGGKYVMYPIAVSGDHENNKMFSNCSKQSIYKTIESKAQECFQERSNKVCGNSRVDEGEECDPGIMYLNNDTCCNSDCTLKEGVQCSDRNSPCCKNCQFETAQKKCQEAINATCKGVSYCTGNSSECPPPGNAEDDTVCLDLGKCKDGKCIPFCEREQQLESCACNETDNSCKVCCRDLSGRCVPYVDAEQKNLFLRKGKPCTVGFCDMNGKCEKRVQDVIERFWDFIDQLSINTFGKFLADNIVGSVLVFSLIFWIPFSILVHCVDKKLDKQYESLSLFHPSNVEMLSSMDSASVRIIKPFPAPQTPGRLQPAPVIPSAPAAPKLDHQRMDTIQEDPSTDSHMDEDGFEKDPFPNSSTAAKSFEDLTDHPVTRSEKAASFKLQRQNRVDSKETEC
  
Inhibitor
Name:
BDBM50247704
Synonyms:
3-(5-(hexa-2,4-dienylidene)-2-oxo-5,6-dihydro-2H-pyran-3-yl)-N-hydroxypropanamide | CHEMBL455409
Type:
Small organic molecule
Emp. Form.:
C14H17NO4
Mol. Mass.:
263.12
SMILES:
C\C=C\C=C\C=C1/COC(=O)C(CCC(=O)NO)=C1 |c:17|
Structure:
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