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Target
DNA gyrase subunit B
Ligand
BDBM50423645
Substrate
n/a
Meas. Tech.
ChEMBL_598030 (CHEMBL1046299)
IC50
37±n/a nM
Citation
 Starr, JT; Sciotti, RJ; Hanna, DL; Huband, MD; Mullins, LM; Cai, H; Gage, JW; Lockard, M; Rauckhorst, MR; Owen, RM; Lall, MS; Tomilo, M; Chen, H; McCurdy, SP; Barbachyn, MR 5-(2-Pyrimidinyl)-imidazo[1,2-a]pyridines are antibacterial agents targeting the ATPase domains of DNA gyrase and topoisomerase IV. Bioorg Med Chem Lett 19:5302-6 (2009) [PubMed]  Article 
Target
Name:
DNA gyrase subunit B
Synonyms:
GYRB_STRPN | gyrB
Type:
PROTEIN
Mol. Mass.:
72222.52
Organism:
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)
Description:
ChEMBL_598030
Residue:
648
Sequence:
MTEEIKNLQAQDYDASQIQVLEGLEAVRMRPGMYIGSTSKEGLHHLVWEIVDNSIDEALAGFASHIQVFIEPDDSITVVDDGRGIPVDIQEKTGRPAVETVFTVLHAGGKFGGGGYKVSGGLHGVGSSVVNALSTQLDVHVHKNGKIHYQEYRRGHVVADLEIVGDTDKTGTTVHFTPDPKIFTETTIFDFDKLNKRIQELAFLNRGLQISITDKRQGLEQTKHYHYEGGIASYVEYINENKDVIFDTPIYTDGEMDDITVEVAMQYTTGYHENVMSFANNIHTHEGGTHEQGFRTALTRVINDYARKNKLLKDNEDNLTGEDVREGLTAVISVKHPNPQFEGQTKTKLGNSEVVKITNRLFSEAFSDFLMENPQIAKRIVEKGILAAKARVAAKRAREVTRKKSGLEISNLPGKLADCSSNNPAETELFIVEGDSAGGSAKSGRNREFQAILPIRGKILNVEKASMDKILANEEIRSLFTAMGTGFGAEFDVSKARYQKLVLMTDADVDGAHIRTLLLTLIYRYMKPILEAGYVYIAQPPIYGVKVGSEIKEYIQPGADQEIKLQEALARYSEGRTKPTIQRYKGLGEMDDHQLWETTMDPEHRLMARVSVDDAAEADKIFDMLMGDRVEPRREFIEENAVYSTLDV
  
Inhibitor
Name:
BDBM50423645
Synonyms:
Albamycin | Cathomycin | NOVOBIOCIN
Type:
Small organic molecule
Emp. Form.:
C31H36N2O11
Mol. Mass.:
612.6243
SMILES:
[#6]-[#8]-[#6@@H]1-[#6@@H](-[#8]-[#6](-[#7])=O)-[#6@H](-[#8])-[#6@@H](-[#8]-c2ccc3c(-[#8])c(-[#7]-[#6](=O)-c4ccc(-[#8])c(-[#6]\[#6]=[#6](\[#6])-[#6])c4)c(=O)oc3c2-[#6])-[#8]C1([#6])[#6]
Structure:
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