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Target
Succinyl-diaminopimelate desuccinylase
Ligand
BDBM50217941
Substrate
n/a
Meas. Tech.
ChEMBL_617887 (CHEMBL1101552)
IC50
50000±n/a nM
Citation
 Gillner, D; Armoush, N; Holz, RC; Becker, DP Inhibitors of bacterial N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE) and demonstration of in vitro antimicrobial activity. Bioorg Med Chem Lett 19:6350-2 (2009) [PubMed]  Article 
Target
Name:
Succinyl-diaminopimelate desuccinylase
Synonyms:
DAPE_HAEIN | dapE
Type:
PROTEIN
Mol. Mass.:
41343.05
Organism:
Haemophilus influenzae
Description:
ChEMBL_617887
Residue:
377
Sequence:
MKEKVVSLAQDLIRRPSISPNDEGCQQIIAERLEKLGFQIEWMPFNDTLNLWAKHGTSEPVIAFAGHTDVVPTGDENQWSSPPFSAEIIDGMLYGRGAADMKGSLAAMIVAAEEYVKANPNHKGTIALLITSDEEATAKDGTIHVVETLMARDEKITYCMVGEPSSAKNLGDVVKNGRRGSITGNLYIQGIQGHVAYPHLAENPIHKAALFLQELTTYQWDKGNEFFPPTSLQIANIHAGTGSNNVIPAELYIQFNLRYCTEVTDEIIKQKVAEMLEKHNLKYRIEWNLSGKPFLTKPGKLLDSITSAIEETIGITPKAETGGGTSDGRFIALMGAEVVEFGPLNSTIHKVNECVSVEDLGKCGEIYHKMLVNLLDS
  
Inhibitor
Name:
BDBM50217941
Synonyms:
(-)-penicillamine | (2S)-2-amino-3-methyl-3-sulfanylbutanoic acid3-sulfanyl-D-valine | (S)-3,3-dimethylcysteine | 3-mercapto-D-valine | CHEMBL1430 | Cuprenil | D-(-)-penicillamine | D-PENICILLAMINE | D-beta,beta-dimethylcysteine | Depen | Penicillamine
Type:
Small organic molecule
Emp. Form.:
C5H11NO2S
Mol. Mass.:
149.211
SMILES:
CC(C)(S)[C@@H](N)C(O)=O |r|
Structure:
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