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Target
Segment polarity protein dishevelled homolog DVL-2
Ligand
BDBM50378801
Substrate
n/a
Meas. Tech.
ChEMBL_651099 (CHEMBL1227540)
Ki
4600±n/a nM
Citation
 Zhang, Y; Appleton, BA; Wiesmann, C; Lau, T; Costa, M; Hannoush, RN; Sidhu, SS Inhibition of Wnt signaling by Dishevelled PDZ peptides. Nat Chem Biol 5:217-9 (2009) [PubMed]  Article 
Target
Name:
Segment polarity protein dishevelled homolog DVL-2
Synonyms:
Dishevelled-2 | DSH homolog 2 | DVL2_HUMAN | DVL2
Type:
PROTEIN
Mol. Mass.:
78940.00
Organism:
Human
Description:
ChEMBL_651099
Residue:
736
Sequence:
MAGSSTGGGGVGETKVIYHLDEEETPYLVKIPVPAERITLGDFKSVLQRPAGAKYFFKSMDQDFGVVKEEISDDNARLPCFNGRVVSWLVSSDNPQPEMAPPVHEPRAELAPPAPPLPPLPPERTSGIGDSRPPSFHPNVSSSHENLEPETETESVVSLRRERPRRRDSSEHGAGGHRTGGPSRLERHLAGYESSSTLMTSELESTSLGDSDEEDTMSRFSSSTEQSSASRLLKRHRRRRKQRPPRLERTSSFSSVTDSTMSLNIITVTLNMEKYNFLGISIVGQSNERGDGGIYIGSIMKGGAVAADGRIEPGDMLLQVNDMNFENMSNDDAVRVLRDIVHKPGPIVLTVAKCWDPSPQAYFTLPRNEPIQPIDPAAWVSHSAALTGTFPAYPGSSSMSTITSGSSLPDGCEGRGLSVHTDMASVTKAMAAPESGLEVRDRMWLKITIPNAFLGSDVVDWLYHHVEGFPERREARKYASGLLKAGLIRHTVNKITFSEQCYYVFGDLSGGCESYLVNLSLNDNDGSSGASDQDTLAPLPGATPWPLLPTFSYQYPAPHPYSPQPPPYHELSSYTYGGGSASSQHSEGSRSSGSTRSDGGAGRTGRPEERAPESKSGSGSESEPSSRGGSLRRGGEASGTSDGGPPPSRGSTGGAPNLRAHPGLHPYGPPPGMALPYNPMMVVMMPPPPPPVPPAVQPPGAPPVRDLGSVPPELTASRQSFHMAMGNPSEFFVDVM
  
Inhibitor
Name:
BDBM50378801
Synonyms:
CHEMBL1222069
Type:
Small organic molecule
Emp. Form.:
C48H74N10O15
Mol. Mass.:
n/a
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)CN)[C@@H](C)CC)C(C)C)C(O)=O |r|
Structure:
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