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Target
Amine oxidase [flavin-containing] B
Ligand
BDBM50169955
Substrate
n/a
Meas. Tech.
ChEMBL_651342 (CHEMBL1227162)
IC50
82±n/a nM
Citation
 Geldenhuys, WJ; Darvesh, AS; Funk, MO; Van der Schyf, CJ; Carroll, RT Identification of novel monoamine oxidase B inhibitors by structure-based virtual screening. Bioorg Med Chem Lett 20:5295-8 (2010) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] B
Synonyms:
AOFB_HUMAN | MAO-B | MAOB | Monoamine oxidase type B | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAO B) | Monoamine oxidase type B (MAOB)
Type:
Protein
Mol. Mass.:
58768.76
Organism:
Human
Description:
P27338
Residue:
520
Sequence:
MSNKCDVVVVGGGISGMAAAKLLHDSGLNVVVLEARDRVGGRTYTLRNQKVKYVDLGGSYVGPTQNRILRLAKELGLETYKVNEVERLIHHVKGKSYPFRGPFPPVWNPITYLDHNNFWRTMDDMGREIPSDAPWKAPLAEEWDNMTMKELLDKLCWTESAKQLATLFVNLCVTAETHEVSALWFLWYVKQCGGTTRIISTTNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIYIDQTRENVLVETLNHEMYEAKYVISAIPPTLGMKIHFNPPLPMMRNQMITRVPLGSVIKCIVYYKEPFWRKKDYCGTMIIDGEEAPVAYTLDDTKPEGNYAAIMGFILAHKARKLARLTKEERLKKLCELYAKVLGSLEALEPVHYEEKNWCEEQYSGGCYTTYFPPGILTQYGRVLRQPVDRIYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWQSEPESVDVPAQPITTTFLERHLPSVPGLLRLIGLTTIFSATALGFLAHKRGLLVRV
  
Inhibitor
Name:
BDBM50169955
Synonyms:
3-(2-Amino-ethyl)-5-[1-(4-ethoxy-phenyl)-meth-(Z)-ylidene]-thiazolidine-2,4-dione | 3-(2-aminoethyl)-5-(4-ethoxybenzylidene)thiazolidine-2,4-dione | CHEMBL363555
Type:
Small organic molecule
Emp. Form.:
C14H16N2O3S
Mol. Mass.:
292.353
SMILES:
CCOc1ccc(\C=C2/SC(=O)N(CCN)C2=O)cc1
Structure:
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