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Target
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Ligand
BDBM50078117
Substrate
n/a
Meas. Tech.
ChEMBL_736246 (CHEMBL1693390)
IC50
150±n/a nM
Citation
 Poláková, M; Šeták, S; Lattová, E; Petruš, L; Mucha, J; Tvaroška, I; Kóna, J a-D-mannose derivatives as models designed for selective inhibition of Golgia-mannosidase II. Eur J Med Chem 46:944-52 (2011) [PubMed]  Article 
Target
Name:
Mannosyl-oligosaccharide alpha-1,2-mannosidase IA
Synonyms:
Mannosidase-1 | Man(9)-alpha-mannosidase | MA1A1_DROME | alpha-Man-Ia | alpha-man-1 | mas-1 | Mannosyl-oligosaccharide alpha-1,2-mannosidase isoform B
Type:
PROTEIN
Mol. Mass.:
74961.37
Organism:
Fruit fly
Description:
ChEMBL_103952
Residue:
667
Sequence:
MYRISPIGRKSNFHSREKCLIGLVLVTLCFLCFGGIFLLPDNFGSDRVLRVYKHFRKAGPEIFIPAPPLAAHAPHRSEDPHFIGDRQRLEQKIRAELGDMLDEPPAAGGGEPGQFQVLAQQAQAPAPVAALADQPLDQDEGHAAIPVLAAPVQGDNAASQASSHPQSSAQQHNQQQPQLPLGGGGNDQAPDTLDATLEERRQKVKEMMEHAWHNYKLYAWGKNELRPLSQRPHSASIFGSYDLGATIVDGLDTLYIMGLEKEYREGRDWIERKFSLDNISAELSVFETNIRFVGGMLTLYAFTGDPLYKEKAQHVADKLLPAFQTPTGIPYALVNTKTGVAKNYGWASGGSSILSEFGTLHLEFAYLSDITGNPLYRERVQTIRQVLKEIEKPKGLYPNFLNPKTGKWGQLHMSLGALGDSYYEYLLKAWLQSGQTDEEAREMFDEAMLAILDKMVRTSPGGLTYVSDLKFDRLEHKMDHLACFSGGLFALGAATRQNDYTDKYMEVGKGITNTCHESYIRAPTQLGPEAFRFSEAVEARALRSQEKYYILRPETFESYFVLWRLTHDQKYRDWGWEAVLALEKHCRTAHGYCGLRNVYQQEPQKDDVQQSFFLAETLKYLYLLFSDDSVLPLDEWVFNTEAHPLPIKGANAYYRQAPVTLPVSNAS
  
Inhibitor
Name:
BDBM50078117
Synonyms:
Mannostatin A, 1 | (1R,2R,3R,4S,5R)-4-Amino-5-methylsulfanyl-cyclopentane-1,2,3-triol | Mannostatin A, 1a | CHEMBL9623 | (1R,2R,3R,4S,5R)-4-AMINO-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
CS[C@@H]1[C@H]([C@H]([C@H]([C@H]1O)O)O)N
Structure:
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