Reaction Details
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Aldo-keto reductase family 1 member C2
Ligand
BDBM50029207
Substrate
n/a
Meas. Tech.
ChEMBL_821630 (CHEMBL2038585)
IC50
6000±n/a nM
Citation
Endo, S; Matsunaga, T; Kanamori, A; Otsuji, Y; Nagai, H; Sundaram, K; El-Kabbani, O; Toyooka, N; Ohta, S; Hara, A Selective inhibition of human type-5 17ß-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolis. J Nat Prod 75:716-21 (2012) [PubMed] Article More Info.:
Target
Name:
Aldo-keto reductase family 1 member C2
Synonyms:
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase | 3-alpha-Hydroxysteroid Dehydrogenase Type 3 (AKR1C2) | Chlordecone reductase homolog HAKRD | Aldo-keto reductase family 1 member C2 (AK1C2) | 3-alpha-HSD3 | Dihydrodiol dehydrogenase 2 | Type III 3-alpha-hydroxysteroid dehydrogenase | Aldo-keto reductase family 1 member C2 (AK1C2a) | DD-2 | DD/BABP | Dihydrodiol dehydrogenase/bile acid-binding protein | Aldo-keto reductase family 1 member C2 (AKR1C2) | AK1C2_HUMAN | AKR1C2 | DDH2
Type:
Enzyme
Mol. Mass.:
36739.89
Organism:
Human
Description:
n/a
Residue:
323
Sequence:
MDSKYQCVKLNDGHFMPVLGFGTYAPAEVPKSKALEAVKLAIEAGFHHIDSAHVYNNEEQVGLAIRSKIADGSVKREDIFYTSKLWSNSHRPELVRPALERSLKNLQLDYVDLYLIHFPVSVKPGEEVIPKDENGKILFDTVDLCATWEAMEKCKDAGLAKSIGVSNFNHRLLEMILNKPGLKYKPVCNQVECHPYFNQRKLLDFCKSKDIVLVAYSALGSHREEPWVDPNSPVLLEDPVLCALAKKHKRTPALIALRYQLQRGVVVLAKSYNEQRIRQNVQVFEFQLTSEEMKAIDGLNRNVRYLTLDIFAGPPNYPFSDEY
Inhibitor
Name:
BDBM50029207
Synonyms:
phenethyl 3-(3,4-dihydroxyphenyl)acrylate | caffeic acid phenylethyl ester | caffeic acid phenethylester | (E)-3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester | caffeic acid phenylethylester | caffeic acidphenethylester | 3-(3,4-Dihydroxy-phenyl)-acrylic acid phenethyl ester | phenethyl caffeate | (E)-phenethyl 3-(3,4-dihydroxyphenyl)acrylate | caffeic acid phenethyl ester | CHEMBL319244 | CAPE
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
c1ccc(cc1)CCOC(=O)/C=C/c2ccc(c(c2)O)O
Structure:
