Reaction Details Report a problem with these data
Target
Ribosyldihydronicotinamide dehydrogenase [quinone]
Ligand
BDBM50402432
Substrate
n/a
Meas. Tech.
ChEMBL_886533 (CHEMBL2215242)
IC50
200±n/a nM
Citation
 Volkova, MS; Jensen, KC; Lozinskaya, NA; Sosonyuk, SE; Proskurnina, MV; Mesecar, AD; Zefirov, NS Synthesis of novel¿¿3 receptor ligands via an unusual Knoevenagel condensation. Bioorg Med Chem Lett 22:7578-81 (2012) [PubMed]  Article 
Target
Name:
Ribosyldihydronicotinamide dehydrogenase [quinone]
Synonyms:
QR2 | Quinone reductase 2 (NQO2) | Metallothionein-3 | NRH:quinone oxidoreductase 2 | Ribosyldihydronicotinamide dehydrogenase [quinone] | NRH dehydrogenase [quinone] 2 | Quinone reductase 2 | NQO2_HUMAN | NQO2 | NMOR2
Type:
Protein
Mol. Mass.:
25917.25
Organism:
Human
Description:
P16083
Residue:
231
Sequence:
MAGKKVLIVYAHQEPKSFNGSLKNVAVDELSRQGCTVTVSDLYAMNLEPRATDKDITGTLSNPEVFNYGVETHEAYKQRSLASDITDEQKKVREADLVIFQFPLYWFSVPAILKGWMDRVLCQGFAFDIPGFYDSGLLQGKLALLSVTTGGTAEMYTKTGVNGDSRYFLWPLQHGTLHFCGFKVLAPQISFAPEIASEEERKGMVAAWSQRLQTIWKEEPIPCTAHWHFGQ
  
Inhibitor
Name:
BDBM50402432
Synonyms:
CHEMBL2208058
Type:
Small organic molecule
Emp. Form.:
C14H17N3O4
Mol. Mass.:
n/a
SMILES:
CC(=O)NCCC1(O)C(=O)Nc2ccc(NC(C)=O)cc12
Structure:
Search PDB for entries with ligand similarity: