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Target
Protein-tyrosine kinase 2-beta
Ligand
BDBM50403002
Substrate
n/a
Meas. Tech.
ChEMBL_885500 (CHEMBL2209552)
IC50
75±n/a nM
Citation
 Bhattacharya, SK; Aspnes, GE; Bagley, SW; Boehm, M; Brosius, AD; Buckbinder, L; Chang, JS; Dibrino, J; Eng, H; Frederick, KS; Griffith, DA; Griffor, MC; Guimarães, CR; Guzman-Perez, A; Han, S; Kalgutkar, AS; Klug-McLeod, J; Garcia-Irizarry, C; Li, J; Lippa, B; Price, DA; Southers, JA; Walker, DP; Wei, L; Xiao, J; Zawistoski, MP; Zhao, X Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett 22:7523-9 (2012) [PubMed]  Article 
Target
Name:
Protein-tyrosine kinase 2-beta
Synonyms:
Protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | FAK2_HUMAN | PTK2B | FAK2 | PYK2 | RAFTK
Type:
Protein
Mol. Mass.:
115868.80
Organism:
Human
Description:
Q14289
Residue:
1009
Sequence:
MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVKCTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYECLHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGCLELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYASLREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLAEFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQGSLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGIAREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKNLDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYLESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFRRFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTRCWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRPKYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMREEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSPLTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQLPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLAQQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
  
Inhibitor
Name:
BDBM50403002
Synonyms:
CHEMBL2207430
Type:
Small organic molecule
Emp. Form.:
C29H36N6O3
Mol. Mass.:
n/a
SMILES:
CCOCCCNC(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Structure:
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