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Target
Focal adhesion kinase 1
Ligand
BDBM50403002
Substrate
n/a
Meas. Tech.
ChEMBL_885494 (CHEMBL2209546)
IC50
>10000±n/a nM
Citation
 Bhattacharya, SK; Aspnes, GE; Bagley, SW; Boehm, M; Brosius, AD; Buckbinder, L; Chang, JS; Dibrino, J; Eng, H; Frederick, KS; Griffith, DA; Griffor, MC; Guimarães, CR; Guzman-Perez, A; Han, S; Kalgutkar, AS; Klug-McLeod, J; Garcia-Irizarry, C; Li, J; Lippa, B; Price, DA; Southers, JA; Walker, DP; Wei, L; Xiao, J; Zawistoski, MP; Zhao, X Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors. Bioorg Med Chem Lett 22:7523-9 (2012) [PubMed]  Article 
Target
Name:
Focal adhesion kinase 1
Synonyms:
FRNK | Focal adhesion kinase (FAK) | Focal adhesion kinase (PTK2) | Focal adhesion kinase 1 (FAK) | Focal adhesion kinase-related nonkinase | Protein phosphatase 1 regulatory subunit 71 | FADK 1 | FLT4 | PPP1R71 | Protein-tyrosine kinase 2 | p125FAK | pp125FAK | FAK1_HUMAN | PTK2 | FAK | FAK1 | VHL/Focal adhesion kinase 1 | Focal adhesion kinase 1/vascular endothelial growth factor receptor 3
Type:
Tyrosine-protein kinase
Mol. Mass.:
119233.17
Organism:
Human
Description:
Q05397
Residue:
1052
Sequence:
MAAAYLDPNLNHTPNSSTKTHLGTGMERSPGAMERVLKVFHYFESNSEPTTWASIIRHGDATDVRGIIQKIVDSHKVKHVACYGFRLSHLRSEEVHWLHVDMGVSSVREKYELAHPPEEWKYELRIRYLPKGFLNQFTEDKPTLNFFYQQVKSDYMLEIADQVDQEIALKLGCLEIRRSYWEMRGNALEKKSNYEVLEKDVGLKRFFPKSLLDSVKAKTLRKLIQQTFRQFANLNREESILKFFEILSPVYRFDKECFKCALGSSWIISVELAIGPEEGISYLTDKGCNPTHLADFTQVQTIQYSNSEDKDRKGMLQLKIAGAPEPLTVTAPSLTIAENMADLIDGYCRLVNGTSQSFIIRPQKEGERALPSIPKLANSEKQGMRTHAVSVSETDDYAEIIDEEDTYTMPSTRDYEIQRERIELGRCIGEGQFGDVHQGIYMSPENPALAVAIKTCKNCTSDSVREKFLQEALTMRQFDHPHIVKLIGVITENPVWIIMELCTLGELRSFLQVRKYSLDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYYKASKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIENGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESRRQATVSWDSGGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQVSGYPGSHGITAMAGSIYPGQASLLDQTDSWNHRPQEIAMWQPNVEDSTVLDLRGIGQVLPTHLMEERLIRQQQEMEEDQRWLEKEERFLKPDVRLSRGSIDREDGSLQGPIGNQHIYQPVGKPDPAAPPKKPPRPGAPGHLGSLASLSSPADSYNEGVKLQPQEISPPPTANLDRSNDKVYENVTGLVKAVIEMSSKIQPAPPEEYVPMVKEVGLALRTLLATVDETIPLLPASTHREIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQARLKMLGQTRPH
  
Inhibitor
Name:
BDBM50403002
Synonyms:
CHEMBL2207430
Type:
Small organic molecule
Emp. Form.:
C29H36N6O3
Mol. Mass.:
n/a
SMILES:
CCOCCCNC(=O)c1cc2cccc(NC(=O)Nc3cc(nn3-c3ccc(C)cc3)C(C)(C)C)c2[nH]1
Structure:
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