Reaction Details Report a problem with these data
Target
3-oxoacyl-[acyl-carrier-protein] synthase 3
Ligand
BDBM23570
Substrate
n/a
Meas. Tech.
ChEMBL_510888 (CHEMBL997780)
IC50
1600±n/a nM
Citation
 Singh, S; Soni, LK; Gupta, MK; Prabhakar, YS; Kaskhedikar, SG QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of beta-ketoacyl-acyl carrier protein synthase III. Eur J Med Chem 43:1071-80 (2008) [PubMed]  Article 
Target
Name:
3-oxoacyl-[acyl-carrier-protein] synthase 3
Synonyms:
Beta-ketoacyl-ACP synthase III | 3-oxoacyl-[acyl-carrier-protein] synthase III | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | KAS III | FABH_ENTFA | fabH | beta-Ketoacyl-ACP Synthase III (FabH)
Type:
Acyltransferase; homodimer
Mol. Mass.:
35176.53
Organism:
Enterococcus faecalis (strain ATCC 700802 / V583)
Description:
The E. faecalis FabH was cloned, and protein was expressed in E. coli.
Residue:
321
Sequence:
MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVAKQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYALSMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKLQADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETVDYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQQRVVLTGFGGGLTWGSLLLTL
  
Inhibitor
Name:
BDBM23570
Synonyms:
2-{[4-bromo-3-(diethylsulfamoyl)benzene]amido}benzoic acid | Diethylsulfonamide Derivative, 13a
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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