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Target
B2 bradykinin receptor
Ligand
BDBM50411275
Substrate
n/a
Meas. Tech.
ChEMBL_806222 (CHEMBL1958763)
Kd
0.0501±n/a nM
Citation
 Fincham, CI; Bressan, A; D'Andrea, P; Ettorre, A; Giuliani, S; Mauro, S; Meini, S; Paris, M; Quartara, L; Rossi, C; Squarcia, A; Valenti, C; Daniela, F; Maggi, CA Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships ofa,a-tetrahydropyranylglycine. Bioorg Med Chem 20:2091-100 (2012) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
Bradykinin B2 receptor | B2R | BK-2 receptor | B2 bradykinin receptor | B2 BRADYKININ | BKRB2_HUMAN | BDKRB2 | BKR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Human
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50411275
Synonyms:
MEN-16132 | CHEMBL218427
Type:
Small organic molecule
Emp. Form.:
C36 H49 Cl2 N6 O6 S
Mol. Mass.:
n/a
SMILES:
Cc1cc(C)c2cccc(OCc3c(Cl)ccc(c3Cl)S(=O)(=O)NC3(CCOCC3)C(=O)N3CCN(CC3)C(=O)[C@@H](N)CCC[N+](C)(C)C)c2n1
Structure:
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