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Target
B2 bradykinin receptor
Ligand
BDBM50419905
Substrate
n/a
Meas. Tech.
ChEMBL_806222 (CHEMBL1958763)
Kd
0.437±n/a nM
Citation
 Fincham, CI; Bressan, A; D'Andrea, P; Ettorre, A; Giuliani, S; Mauro, S; Meini, S; Paris, M; Quartara, L; Rossi, C; Squarcia, A; Valenti, C; Daniela, F; Maggi, CA Design and synthesis of novel sulfonamide-containing bradykinin hB(2) receptor antagonists. Synthesis and structure-relationships ofa,a-tetrahydropyranylglycine. Bioorg Med Chem 20:2091-100 (2012) [PubMed]  Article 
Target
Name:
B2 bradykinin receptor
Synonyms:
Bradykinin B2 receptor | B2R | BK-2 receptor | B2 bradykinin receptor | B2 BRADYKININ | BKRB2_HUMAN | BDKRB2 | BKR2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44467.17
Organism:
Human
Description:
B2 BRADYKININ BDKRB2 HUMAN::P30411
Residue:
391
Sequence:
MFSPWKISMFLSVREDSVPTTASFSADMLNVTLQGPTLNGTFAQSKCPQVEWLGWLNTIQPPFLWVLFVLATLENIFVLSVFCLHKSSCTVAEIYLGNLAAADLILACGLPFWAITISNNFDWLFGETLCRVVNAIISMNLYSSICFLMLVSIDRYLALVKTMSMGRMRGVRWAKLYSLVIWGCTLLLSSPMLVFRTMKEYSDEGHNVTACVISYPSLIWEVFTNMLLNVVGFLLPLSVITFCTMQIMQVLRNNEMQKFKEIQTERRATVLVLVVLLLFIICWLPFQISTFLDTLHRLGILSSCQDERIIDVITQIASFMAYSNSCLNPLVYVIVGKRFRKKSWEVYQGVCQKGGCRSEPIQMENSMGTLRTSISVERQIHKLQDWAGSRQ
  
Inhibitor
Name:
BDBM50419905
Synonyms:
CHEMBL1956853
Type:
Small organic molecule
Emp. Form.:
C37H46Cl2F3N5O8S
Mol. Mass.:
n/a
SMILES:
CN(C)CCCCC(=O)N1CCN(CC1)C(=O)C1(CCOCC1)NS(=O)(=O)c1ccc(Cl)c(COc2cccc3c(C)cc(C)nc23)c1Cl
Structure:
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