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Target
Mitogen-activated protein kinase 14
Ligand
BDBM50425355
Substrate
n/a
Meas. Tech.
ChEMBL_933870 (CHEMBL2317231)
IC50
32±n/a nM
Citation
 Fischer, S; Wentsch, HK; Mayer-Wrangowski, SC; Zimmermann, M; Bauer, SM; Storch, K; Niess, R; Koeberle, SC; Grütter, C; Boeckler, FM; Rauh, D; Laufer, SA Dibenzosuberones as p38 mitogen-activated protein kinase inhibitors with low ATP competitiveness and outstanding whole blood activity. J Med Chem 56:241-53 (2013) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
MK14_HUMAN | MAPK14 | CSBP | CSBP1 | CSBP2 | CSPB1 | MXI2 | SAPK2A | CSAID-binding protein | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAX-interacting protein 2 | Mitogen-activated protein kinase p38 alpha | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Human
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM50425355
Synonyms:
CHEMBL2316494
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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