Reaction Details Report a problem with these data
Target
NAD-dependent protein deacetylase sirtuin-1
Ligand
BDBM31926
Substrate
n/a
Meas. Tech.
ChEMBL_948493 (CHEMBL2343194)
EC50
7000±n/a nM
Citation
 Wu, J; Zhang, D; Chen, L; Li, J; Wang, J; Ning, C; Yu, N; Zhao, F; Chen, D; Chen, X; Chen, K; Jiang, H; Liu, H; Liu, D Discovery and mechanism study of SIRT1 activators that promote the deacetylation of fluorophore-labeled substrate. J Med Chem 56:761-80 (2013) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-1
Synonyms:
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) | SIR2-like protein 1 | Sirtuin-1 (SIRT1) | Sirtuin 1 (SIRT1) | NAD-dependent deacetylase sirtuin 1 | hSIR2 | SIR1_HUMAN | SIRT1 | SIR2L1 | NAD-Dependent Deacetylase Sirtuin-1
Type:
Developmental protein; hydrolase
Mol. Mass.:
81626.66
Organism:
Human
Description:
n/a
Residue:
747
Sequence:
MADEAALALQPGGSPSAAGADREAASSPAGEPLRKRPRRDGPGLERSPGEPGGAAPEREVPAAARGCPGAAAAALWREAEAEAAAAGGEQEAQATAAAGEGDNGPGLQGPSREPPLADNLYDEDDDDEGEEEEEAAAAAIGYRDNLLFGDEIITNGFHSCESDEEDRASHASSSDWTPRPRIGPYTFVQQHLMIGTDPRTILKDLLPETIPPPELDDMTLWQIVINILSEPPKRKKRKDINTIEDAVKLLQECKKIIVLTGAGVSVSCGIPDFRSRDGIYARLAVDFPDLPDPQAMFDIEYFRKDPRPFFKFAKEIYPGQFQPSLCHKFIALSDKEGKLLRNYTQNIDTLEQVAGIQRIIQCHGSFATASCLICKYKVDCEAVRGDIFNQVVPRCPRCPADEPLAIMKPEIVFFGENLPEQFHRAMKYDKDEVDLLIVIGSSLKVRPVALIPSSIPHEVPQILINREPLPHLHFDVELLGDCDVIINELCHRLGGEYAKLCCNPVKLSEITEKPPRTQKELAYLSELPPTPLHVSEDSSSPERTSPPDSSVIVTLLDQAAKSNDDLDVSESKGCMEEKPQEVQTSRNVESIAEQMENPDLKNVGSSTGEKNERTSVAGTVRKCWPNRVAKEQISRRLDGNQYLFLPPNRYIFHGAEVYSDSEDDVLSSSSCGSNSDSGTCQSPSLEEPMEDESEIEEFYNGLEDEPDVPERAGGAGFGTDGDDQEAINEAISVKQEVTDMNYPSNKS
  
Inhibitor
Name:
BDBM31926
Synonyms:
carbohydrazide derivative, 3i
Type:
Small organic molecule
Emp. Form.:
C14H9Br2ClN2O3
Mol. Mass.:
445.87
SMILES:
c1cc(ccc1C(=O)N/N=C/c2cc(c(c(c2O)Br)O)Br)Cl
Structure:
Search PDB for entries with ligand similarity: