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Target
Acid ceramidase
Ligand
BDBM29080
Substrate
n/a
Meas. Tech.
ChEMBL_949260 (CHEMBL2346136)
Ki
500000±n/a nM
Citation
 Pizzirani, D; Pagliuca, C; Realini, N; Branduardi, D; Bottegoni, G; Mor, M; Bertozzi, F; Scarpelli, R; Piomelli, D; Bandiera, T Discovery of a new class of highly potent inhibitors of acid ceramidase: synthesis and structure-activity relationship (SAR). J Med Chem 56:3518-30 (2013) [PubMed]  Article 
Target
Name:
Acid ceramidase
Synonyms:
ASAH | ASAH1 | ASAH1_HUMAN | Acid ceramidase | Acid ceramidase (AC)
Type:
Enzyme
Mol. Mass.:
44662.65
Organism:
Homo sapiens (Human)
Description:
Q13510
Residue:
395
Sequence:
MPGRSCVALVLLAAAVSCAVAQHAPPWTEDCRKSTYPPSGPTYRGAVPWYTINLDLPPYKRWHELMLDKAPVLKVIVNSLKNMINTFVPSGKIMQVVDEKLPGLLGNFPGPFEEEMKGIAAVTDIPLGEIISFNIFYELFTICTSIVAEDKKGHLIHGRNMDFGVFLGWNINNDTWVITEQLKPLTVNLDFQRNNKTVFKASSFAGYVGMLTGFKPGLFSLTLNERFSINGGYLGILEWILGKKDVMWIGFLTRTVLENSTSYEEAKNLLTKTKILAPAYFILGGNQSGEGCVITRDRKESLDVYELDAKQGRWYVVQTNYDRWKHPFFLDDRRTPAKMCLNRTSQENISFETMYDVLSTKPVLNKLTVYTTLIDVTKGQFETYLRDCPDPCIGW
  
Inhibitor
Name:
BDBM29080
Synonyms:
CHEMBL280065 | N-oleoylethanolamine | Oleamide MEA | Oleoyl monoethanolamide | Oleoylethanolamide (OEA)
Type:
n/a
Emp. Form.:
C20H39NO2
Mol. Mass.:
325.5292
SMILES:
CCCCCCCC\C=C/CCCCCCCC(=O)NCCO
Structure:
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