Reaction Details Report a problem with these data
Target
Aldo-keto reductase family 1 member B1 [K65Q]
Ligand
BDBM50437452
Substrate
n/a
Meas. Tech.
ChEMBL_974577 (CHEMBL2410165)
IC50
99±n/a nM
Citation
 Wang, QQ; Cheng, N; Zheng, XW; Peng, SM; Zou, XQ Synthesis of organic nitrates of luteolin as a novel class of potent aldose reductase inhibitors. Bioorg Med Chem 21:4301-10 (2013) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1 [K65Q]
Synonyms:
ALDR_BOVIN | AKR1B1 | Aldose reductase
Type:
Protein
Mol. Mass.:
35916.27
Organism:
Bovine
Description:
P16116[K65Q]
Residue:
315
Sequence:
AHNIVLYTGAKMPILGLGTWKSPPGKVTEAVKVAIDLGYRHIDCAHVYQNENEVGLALQAKLQEQVVKREDLFIVSKLWCTYHDKDLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKDFFPLDEDGNVIPSEKDFVDTWTAMEELVDEGLVKAIGVSNFNHLQVEKILNKPGLKYKPAVNQIECHPYLTQEKLIQYCNSKGIVVTAYSPLGSPDRPWAKPEDPSILEDPRIKAIADKYNKTTAQVLIRFPIQRNLIVIPKSVTPERIAENFQVFDFELDKEDMNTLLSYNRDWRACALVSCASHRDYPFHEEF
  
Inhibitor
Name:
BDBM50437452
Synonyms:
CHEMBL2409349
Type:
Small organic molecule
Emp. Form.:
C19H15NO9
Mol. Mass.:
401.32
SMILES:
Oc1cc(OCCO[N+]([O-])=O)cc2oc(cc(=O)c12)-c1ccc2OCCOc2c1
Structure:
Search PDB for entries with ligand similarity: