Reaction Details Report a problem with these data
Target
O-acetylserine sulfhydrylase
Ligand
BDBM50427257
Substrate
n/a
Meas. Tech.
ChEMBL_978242 (CHEMBL2423611)
Ki
5000±n/a nM
Citation
 Poyraz, O; Jeankumar, VU; Saxena, S; Schnell, R; Haraldsson, M; Yogeeswari, P; Sriram, D; Schneider, G Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis. J Med Chem 56:6457-66 (2013) [PubMed]  Article 
Target
Name:
O-acetylserine sulfhydrylase
Synonyms:
CSase A | Cysteine synthase A | MT2397 | O-acetylserine (thiol)-lyase A | O-acetylserine-specific cysteine synthase | OAS sulfhydrylase | OAS-TL A | OASS | Sulfide-dependent cysteine synthase | CYSK_MYCTU | cysK1 | cysK
Type:
PROTEIN
Mol. Mass.:
32747.29
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_978239
Residue:
310
Sequence:
MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVVLPDFGERYLSTPLFADVAD
  
Inhibitor
Name:
BDBM50427257
Synonyms:
CHEMBL2325118
Type:
Small organic molecule
Emp. Form.:
C22H32N4O8
Mol. Mass.:
480.51
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O)C(O)=O |r|
Structure:
Search PDB for entries with ligand similarity: