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Target
O-acetylserine sulfhydrylase
Ligand
BDBM50439140
Substrate
n/a
Meas. Tech.
ChEMBL_978239 (CHEMBL2423608)
IC50
37±n/a nM
Citation
 Poyraz, O; Jeankumar, VU; Saxena, S; Schnell, R; Haraldsson, M; Yogeeswari, P; Sriram, D; Schneider, G Structure-guided design of novel thiazolidine inhibitors of O-acetyl serine sulfhydrylase from Mycobacterium tuberculosis. J Med Chem 56:6457-66 (2013) [PubMed]  Article 
Target
Name:
O-acetylserine sulfhydrylase
Synonyms:
CSase A | CYSK_MYCTU | Cysteine synthase A | MT2397 | O-acetylserine (thiol)-lyase A | O-acetylserine-specific cysteine synthase | OAS sulfhydrylase | OAS-TL A | OASS | Sulfide-dependent cysteine synthase | cysK | cysK1
Type:
PROTEIN
Mol. Mass.:
32747.29
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
ChEMBL_978239
Residue:
310
Sequence:
MSIAEDITQLIGRTPLVRLRRVTDGAVADIVAKLEFFNPANSVKDRIGVAMLQAAEQAGLIKPDTIILEPTSGNTGIALAMVCAARGYRCVLTMPETMSLERRMLLRAYGAELILTPGADGMSGAIAKAEELAKTDQRYFVPQQFENPANPAIHRVTTAEEVWRDTDGKVDIVVAGVGTGGTITGVAQVIKERKPSARFVAVEPAASPVLSGGQKGPHPIQGIGAGFVPPVLDQDLVDEIITVGNEDALNVARRLAREEGLLVGISSGAATVAALQVARRPENAGKLIVVVLPDFGERYLSTPLFADVAD
  
Inhibitor
Name:
BDBM50439140
Synonyms:
CHEMBL2418487
Type:
Small organic molecule
Emp. Form.:
C20H19N3O3S
Mol. Mass.:
381.448
SMILES:
CN(C)c1ccc(\C=C2/S\C(=N/c3cccc(c3)C(O)=O)N(C)C2=O)cc1
Structure:
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