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Target
Thymidine phosphorylase
Ligand
BDBM50443011
Substrate
n/a
Meas. Tech.
ChEMBL_1275628 (CHEMBL3090759)
IC50
>100000±n/a nM
Citation
 Renck, D; Machado, P; Souto, AA; Rosado, LA; Erig, T; Campos, MM; Farias, CB; Roesler, R; Timmers, LF; de Souza, ON; Santos, DS; Basso, LA Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem 56:8892-902 (2013) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TdRPase | PD-ECGF | Gliostatin | Platelet-derived endothelial cell growth factor | TP | TYPH_HUMAN | TYMP | ECGF1 | Thymidine phosphorylase | Thymidine Phosphorylase (TP)
Type:
Enzyme
Mol. Mass.:
49948.87
Organism:
Human
Description:
The recombinant human thymidine phosphorylase (V79TP) was expressed in V79 Chinese hamster cells (Sigma, T-9319).
Residue:
482
Sequence:
MAALMTPGTGAPPAPGDFSGEGSQGLPDPSPEPKQLPELIRMKRDGGRLSEADIRGFVAAVVNGSAQGAQIGAMLMAIRLRGMDLEETSVLTQALAQSGQQLEWPEAWRQQLVDKHSTGGVGDKVSLVLAPALAACGCKVPMISGRGLGHTGGTLDKLESIPGFNVIQSPEQMQVLLDQAGCCIVGQSEQLVPADGILYAARDVTATVDSLPLITASILSKKLVEGLSALVVDVKFGGAAVFPNQEQARELAKTLVGVGASLGLRVAAALTAMDKPLGRCVGHALEVEEALLCMDGAGPPDLRDLVTTLGGALLWLSGHAGTQAQGAARVAAALDDGSALGRFERMLAAQGVDPGLARALCSGSPAERRQLLPRAREQEELLAPADGTVELVRALPLALVLHELGAGRSRAGEPLRLGVGAELLVDVGQRLRRGTPWLRVHRDGPALSGPQSRALQEALVLSDRAPFAAPSPFAELVLPPQQ
  
Inhibitor
Name:
BDBM50443011
Synonyms:
CHEMBL3087493
Type:
Small organic molecule
Emp. Form.:
C10H13N3O2
Mol. Mass.:
207.23
SMILES:
CN(C)Cc1c(O)[nH]c(=O)c(C#N)c1C
Structure:
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