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Target
Acetylcholine receptor subunit epsilon
Ligand
BDBM50448376
Substrate
n/a
Meas. Tech.
ChEMBL_1292388 (CHEMBL3123981)
IC50
41687±n/a nM
Citation
 Matera, C; Flammini, L; Quadri, M; Vivo, V; Ballabeni, V; Holzgrabe, U; Mohr, K; De Amici, M; Barocelli, E; Bertoni, S; Dallanoce, C Bis(ammonio)alkane-type agonists of muscarinic acetylcholine receptors: synthesis, in vitro functional characterization, and in vivo evaluation of their analgesic activity. Eur J Med Chem 75:222-32 (2014) [PubMed]  Article 
Target
Name:
Acetylcholine receptor subunit epsilon
Synonyms:
ACHE_RAT | Acetylcholine receptor protein epsilon chain | Achre | Chrne
Type:
PROTEIN
Mol. Mass.:
54930.09
Organism:
Rattus norvegicus
Description:
ChEMBL_1292388
Residue:
494
Sequence:
MTMALLGTLLLLALFGRSQGKNEELSLYHHLFDNYDPECRPVRRPEDTVTITLKVTLTNLISLNEKEETLTTSVWIGIEWQDYRLNFSKDDFAGVEILRVPSEHVWLPEIVLENNIDGQFGVAYDCNVLVYEGGSVSWLPPAIYRSTCAVEVTYFPFDWQNCSLIFRSQTYNAEEVELIFAVDDDGNAINKIDIDTAAFTENGEWAIDYCPGMIRHYEGGSTEDPGETDVIYTLIIRRKPLFYVINIIVPCVLISGLVLLAYFLPAQAGGQKCTVSINVLLAQTVFLFLIAQKIPETSLSVPLLGRYLIFVMVVATLIVMNCVIVLNVSLRTPTTHATSPRLRQILLELLPRLLGLSPPPEDPGAASPARRASSVGILLRAEELILKKPRSELVFEGQRHRHGTWTAAALCQNLGAAAPEVRCCVDAVNFVAESTRDQEATGEELSDWVRMGKALDNVCFWAALVLFSVGSTLIFLGGYFNQVPDLPYPPCIQP
  
Inhibitor
Name:
BDBM50448376
Synonyms:
Naphmethonium
Type:
Small organic molecule
Emp. Form.:
C38H50N4O4
Mol. Mass.:
626.8269
SMILES:
CC(C)(CN1C(=O)c2cccc3cccc(C1=O)c23)C[N+](C)(C)CCCCCC[N+](C)(C)CCCN1C(=O)c2ccccc2C1=O
Structure:
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