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Target
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Ligand
BDBM50027699
Substrate
n/a
Meas. Tech.
ChEMBL_1435383 (CHEMBL3383457)
Ki
37±n/a nM
Citation
 Ferla, S; Gomaa, MS; Brancale, A; Zhu, J; Ochalek, JT; DeLuca, HF; Simons, C Novel styryl-indoles as small molecule inhibitors of 25-hydroxyvitamin D-24-hydroxylase (CYP24A1): Synthesis and biological evaluation. Eur J Med Chem 87:39-51 (2014) [PubMed]  Article 
Target
Name:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
Synonyms:
1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial | Cytochrome P450 24A1 | CP24A_HUMAN | CYP24A1 | CYP24
Type:
Protein
Mol. Mass.:
58889.66
Organism:
Human
Description:
Q07973
Residue:
514
Sequence:
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR
  
Inhibitor
Name:
BDBM50027699
Synonyms:
CHEMBL3344396
Type:
Small organic molecule
Emp. Form.:
C22H21N3
Mol. Mass.:
327.17
SMILES:
C(Cn1ccnc1)Cn1ccc2cc(\C=C\c3ccccc3)ccc12
Structure:
Search PDB for entries with ligand similarity: