Reaction Details Report a problem with these data
Target
Growth hormone secretagogue receptor type 1
Ligand
BDBM50047479
Substrate
n/a
Meas. Tech.
ChEMBL_1449409 (CHEMBL3373238)
IC50
0.690000±n/a nM
Citation
 McCoull, W; Barton, P; Brown, AJ; Bowker, SS; Cameron, J; Clarke, DS; Davies, RD; Dossetter, AG; Ertan, A; Fenwick, M; Green, C; Holmes, JL; Martin, N; Masters, D; Moore, JE; Newcombe, NJ; Newton, C; Pointon, H; Robb, GR; Sheldon, C; Stokes, S; Morgan, D Identification, optimization, and pharmacology of acylurea GHS-R1a inverse agonists. J Med Chem 57:6128-40 (2014) [PubMed]  Article 
Target
Name:
Growth hormone secretagogue receptor type 1
Synonyms:
Ghrelin receptor 1a (GHS-R1a) | GH-releasing peptide receptor | Ghrelin Receptor (Growth Hormone Secretagogue Receptor Type 1) | GHS-R | GHRP | GHSR_HUMAN | GHSR | Ghrelin receptor
Type:
Receptor
Mol. Mass.:
41334.57
Organism:
Human
Description:
Receptor binding studies use plasma membranes from LLC PK-1 cells transiently transfected with hGHSR1a.
Residue:
366
Sequence:
MWNATPSEEPGFNLTLADLDWDASPGNDSLGDELLQLFPAPLLAGVTATCVALFVVGIAGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRLWQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVKLVIFVIWAVAFCSAGPIFVLVGVEHENGTDPWDTNECRPTEFAVRSGLLTVMVWVSSIFFFLPVFCLTVLYSLIGRKLWRRRRGDAVVGASLRDQNHKQTVKMLAVVVFAFILCWLPFHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFRLLGFEPFSQRKLSTLKDESSRAWTESSINT
  
Inhibitor
Name:
BDBM50047479
Synonyms:
CHEMBL3319224
Type:
Small organic molecule
Emp. Form.:
C28H29ClN6O4S2
Mol. Mass.:
612.14
SMILES:
CN1CCN(CCCS(=O)(=O)c2ccc3nc(NC(=O)NC(=O)c4cc(ccc4Cl)-c4ccccn4)sc3c2)CC1
Structure:
Search PDB for entries with ligand similarity: