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Target
Eukaryotic elongation factor 2 kinase
Ligand
BDBM50053584
Substrate
n/a
Meas. Tech.
ChEMBL_1446963 (CHEMBL3373720)
IC50
420±n/a nM
Citation
 Edupuganti, R; Wang, Q; Tavares, CD; Chitjian, CA; Bachman, JL; Ren, P; Anslyn, EV; Dalby, KN Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors. Bioorg Med Chem 22:4910-6 (2014) [PubMed]  Article 
Target
Name:
Eukaryotic elongation factor 2 kinase
Synonyms:
Eukaryotic elongation factor 2 kinase (EEF2K) | Eukaryotic elongation factor 2 kinase (eEF-2K) | eEF-2 kinase | eEF-2K | Calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase | EF2K_HUMAN | EEF2K | Serine/threonine-protein kinase EEF2K
Type:
Protein
Mol. Mass.:
82116.99
Organism:
Human
Description:
n/a
Residue:
725
Sequence:
MADEDLIFRLEGVDGGQSPRAGHDGDSDGDSDDEEGYFICPITDDPSSNQNVNSKVNKYYSNLTKSERYSSSGSPANSFHFKEAWKHAIQKAKHMPDPWAEFHLEDIATERATRHRYNAVTGEWLDDEVLIKMASQPFGRGAMRECFRTKKLSNFLHAQQWKGASNYVAKRYIEPVDRDVYFEDVRLQMEAKLWGEEYNRHKPPKQVDIMQMCIIELKDRPGKPLFHLEHYIEGKYIKYNSNSGFVRDDNIRLTPQAFSHFTFERSGHQLIVVDIQGVGDLYTDPQIHTETGTDFGDGNLGVRGMALFFYSHACNRICESMGLAPFDLSPRERDAVNQNTKLLQSAKTILRGTEEKCGSPQVRTLSGSRPPLLRPLSENSGDENMSDVTFDSLPSSPSSATPHSQKLDHLHWPVFSDLDNMASRDHDHLDNHRESENSGDSGYPSEKRGELDDPEPREHGHSYSNRKYESDEDSLGSSGRVCVEKWNLLNSSRLHLPRASAVALEVQRLNALDLEKKIGKSILGKVHLAMVRYHEGGRFCEKGEEWDQESAVFHLEHAANLGELEAIVGLGLMYSQLPHHILADVSLKETEENKTKGFDYLLKAAEAGDRQSMILVARAFDSGQNLSPDRCQDWLEALHWYNTALEMTDCDEGGEYDGMQDEPRYMMLAREAEMLFTGGYGLEKDPQRSGDLYTQAAEAAMEAMKGRLANQYYQKAEEAWAQMEE
  
Inhibitor
Name:
BDBM50053584
Synonyms:
CHEMBL1977874
Type:
Small organic molecule
Emp. Form.:
C13H15N5O3
Mol. Mass.:
289.12
SMILES:
CCN1C(=O)c2cc(c(nc2N(C1=O)C3CC3)N)C(=O)N
Structure:
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