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Target
Cruzipain
Ligand
BDBM50378783
Substrate
n/a
Meas. Tech.
ChEMBL_1469716 (CHEMBL3413254)
IC50
40000±n/a nM
Citation
 Bellera, CL; Balcazar, DE; Vanrell, MC; Casassa, AF; Palestro, PH; Gavernet, L; Labriola, CA; Gálvez, J; Bruno-Blanch, LE; Romano, PS; Carrillo, C; Talevi, A Computer-guided drug repurposing: identification of trypanocidal activity of clofazimine, benidipine and saquinavir. Eur J Med Chem 93:338-48 (2015) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
Cruzain | Cruzaine | Major cysteine proteinase | CYSP_TRYCR
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50378783
Synonyms:
CLOFAZIMINE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: