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Target
P2X purinoceptor 7
Ligand
BDBM50075452
Substrate
n/a
Meas. Tech.
ChEMBL_1473820 (CHEMBL3418719)
IC50
14±n/a nM
Citation
 Park, JH; Lee, GE; Lee, SD; Hien, TT; Kim, S; Yang, JW; Cho, JH; Ko, H; Lim, SC; Kim, YG; Kang, KW; Kim, YC Discovery of novel 2,5-dioxoimidazolidine-based P2X(7) receptor antagonists as constrained analogues of KN62. J Med Chem 58:2114-34 (2015) [PubMed]  Article 
Target
Name:
P2X purinoceptor 7
Synonyms:
ATP receptor | P2X purinoceptor 7 (P2RX7) | P2X purinoceptor 7 (P2X7) | P2X7 | P2Z receptor | Purinergic receptor | P2RX7_HUMAN | P2RX7
Type:
Protein
Mol. Mass.:
68602.85
Organism:
Human
Description:
Q99572
Residue:
595
Sequence:
MPACCSCSDVFQYETNKVTRIQSMNYGTIKWFFHVIIFSYVCFALVSDKLYQRKEPVISSVHTKVKGIAEVKEEIVENGVKKLVHSVFDTADYTFPLQGNSFFVMTNFLKTEGQEQRLCPEYPTRRTLCSSDRGCKKGWMDPQSKGIQTGRCVVYEGNQKTCEVSAWCPIEAVEEAPRPALLNSAENFTVLIKNNIDFPGHNYTTRNILPGLNITCTFHKTQNPQCPIFRLGDIFRETGDNFSDVAIQGGIMGIEIYWDCNLDRWFHHCRPKYSFRRLDDKTTNVSLYPGYNFRYAKYYKENNVEKRTLIKVFGIRFDILVFGTGGKFDIIQLVVYIGSTLSYFGLAAVFIDFLIDTYSSNCCRSHIYPWCKCCQPCVVNEYYYRKKCESIVEPKPTLKYVSFVDESHIRMVNQQLLGRSLQDVKGQEVPRPAMDFTDLSRLPLALHDTPPIPGQPEEIQLLRKEATPRSRDSPVWCQCGSCLPSQLPESHRCLEELCCRKKPGACITTSELFRKLVLSRHVLQFLLLYQEPLLALDVDSTNSRLRHCAYRCYATWRFGSQDMADFAILPSCCRWRIRKEFPKSEGQYSGFKSPY
  
Inhibitor
Name:
BDBM50075452
Synonyms:
CHEMBL3415315
Type:
Small organic molecule
Emp. Form.:
C35H38N4O6S
Mol. Mass.:
642.25
SMILES:
O=C(N1CCC(CC1)N1C(Cc2ccc(OS(=O)(=O)c3cccc4cnccc34)cc2)C(=O)NC1=O)C12CC3CC(CC(C3)C1)C2 |TLB:45:36:43:39.40.41,THB:41:40:37:43.42.44,41:42:39.40.45:37,45:40:43:36.37.44,1:36:43:39.40.41|
Structure:
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