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Target
Amine oxidase [flavin-containing] A
Ligand
BDBM15581
Substrate
n/a
Meas. Tech.
ChEMBL_1471538 (CHEMBL3420101)
IC50
3.1±n/a nM
Citation
 Abd El-Gaber, MK; Hassan, HY; Mahfouz, NM; Farag, HH; Bekhit, AA Synthesis, biological investigation and molecular docking study of N-malonyl-1,2-dihydroisoquinoline derivatives as brain specific and shelf-stable MAO inhibitors. Eur J Med Chem 93:481-91 (2015) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
Amine oxidase [flavin-containing] A | MAO-A | Monoamine oxidase type A | Monoamine oxidase A | AOFA_BOVIN | MAOA | Monoamine oxidase | Monoamine Oxidase Type A (MAO-A)
Type:
PROTEIN
Mol. Mass.:
59764.63
Organism:
Bovine
Description:
ChEMBL_1501477
Residue:
527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHVDYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKLRSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADRLAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAEDVPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
  
Inhibitor
Name:
BDBM15581
Synonyms:
US8633208, Clorgyline | [3-(2,4-dichlorophenoxy)propyl](methyl)prop-2-yn-1-ylamine | CHEMBL8706 | CLG | CLORGILINE | N-[3-(2,4-dichlorophenoxy)propyl]-N-methyl-prop-2-yn-1-amine | Clorgyline | US9603833, Clorgyline
Type:
Small organic molecule
Emp. Form.:
C13H15Cl2NO
Mol. Mass.:
271.05
SMILES:
C[N@](CCCOc1ccc(cc1Cl)Cl)CC#C
Structure:
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