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Target
UDP-glucuronosyltransferase 1A1
Ligand
BDBM25759
Substrate
n/a
Meas. Tech.
ChEMBL_1486476 (CHEMBL3531466)
IC50
12000±n/a nM
Citation
 Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos 39:322-9 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A1
Synonyms:
UGT-1A | UDPGT 1-1 | Bilirubin-specific UDPGT isozyme 1 | UDP-glucuronosyltransferase 1A1 | UGT1.1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UGT1*1 | UGT1A | UGT1-01 | hUG-BR1 | UD11_HUMAN | UGT1A1 | GNT1 | UGT1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1
Type:
Enzyme
Mol. Mass.:
59604.34
Organism:
Human
Description:
P22309
Residue:
533
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM25759
Synonyms:
[3-(9H-carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine | Dilatrend | Coreg | CHEMBL723 | Eucardic | Carvedilol
Type:
Small organic molecule
Emp. Form.:
C24H26N2O4
Mol. Mass.:
406.19
SMILES:
COc1ccccc1OCCNCC(O)COc1cccc2[nH]c3ccccc3c12
Structure:
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