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Target
UDP-glucuronosyltransferase 1A1
Ligand
BDBM50088504
Substrate
n/a
Meas. Tech.
ChEMBL_1486476 (CHEMBL3531466)
IC50
1700±n/a nM
Citation
 Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos 39:322-9 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A1
Synonyms:
UGT-1A | UDPGT 1-1 | Bilirubin-specific UDPGT isozyme 1 | UDP-glucuronosyltransferase 1A1 | UGT1.1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UGT1*1 | UGT1A | UGT1-01 | hUG-BR1 | UD11_HUMAN | UGT1A1 | GNT1 | UGT1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1
Type:
Enzyme
Mol. Mass.:
59604.34
Organism:
Human
Description:
P22309
Residue:
533
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50088504
Synonyms:
CHEBI:45409 | A-84538 | ABBOTT-84538 | Norvir | Ritonavir
Type:
Small organic molecule
Emp. Form.:
C37H48N6O5S2
Mol. Mass.:
720.31
SMILES:
CC(C)[C@H](NC(=O)N(C)Cc1csc(n1)C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1cncs1)Cc1ccccc1 |r|
Structure:
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