Reaction Details Report a problem with these data
Target
UDP-glucuronosyltransferase 1A1
Ligand
BDBM50187243
Substrate
n/a
Meas. Tech.
ChEMBL_1486475 (CHEMBL3531465)
IC50
21000±n/a nM
Citation
 Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos 39:322-9 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A1
Synonyms:
UGT-1A | UDPGT 1-1 | Bilirubin-specific UDPGT isozyme 1 | UDP-glucuronosyltransferase 1A1 | UGT1.1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UGT1*1 | UGT1A | UGT1-01 | hUG-BR1 | UD11_HUMAN | UGT1A1 | GNT1 | UGT1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1
Type:
Enzyme
Mol. Mass.:
59604.34
Organism:
Human
Description:
P22309
Residue:
533
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50187243
Synonyms:
ethinyloestradiol | 17alpha-ethynylestra-1,3,5(10)-triene-3,17beta-diol | 17alpha-ethynylestradiol | 17-ethinyl-3,17-estradiol | 17-ethinyl-3,17-oestradiol | 17-ethinylestradiol | 17alpha-Ethinyl estradiol | CHEMBL691 | Ethinylestradiol | Ethynyl estradiol | ETHINYL ESTRADIOL
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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