Reaction Details Report a problem with these data
Target
UDP-glucuronosyltransferase 1A1
Ligand
BDBM50022178
Substrate
n/a
Meas. Tech.
ChEMBL_1486475 (CHEMBL3531465)
IC50
100000±n/a nM
Citation
 Zhou, J; Tracy, TS; Remmel, RP Correlation between bilirubin glucuronidation and estradiol-3-gluronidation in the presence of model UDP-glucuronosyltransferase 1A1 substrates/inhibitors. Drug Metab Dispos 39:322-9 (2011) [PubMed]  Article 
Target
Name:
UDP-glucuronosyltransferase 1A1
Synonyms:
UGT-1A | UDPGT 1-1 | Bilirubin-specific UDPGT isozyme 1 | UDP-glucuronosyltransferase 1A1 | UGT1.1 | UDP-glucuronosyltransferase 1-1 | UDP-glucuronosyltransferase 1-A | UGT1*1 | UGT1A | UGT1-01 | hUG-BR1 | UD11_HUMAN | UGT1A1 | GNT1 | UGT1 | Uridine-5'-diphosphoglucuronosyltransferase 1A1
Type:
Enzyme
Mol. Mass.:
59604.34
Organism:
Human
Description:
P22309
Residue:
533
Sequence:
MAVESQGGRPLVLGLLLCVLGPVVSHAGKILLIPVDGSHWLSMLGAIQQLQQRGHEIVVLAPDASLYIRDGAFYTLKTYPVPFQREDVKESFVSLGHNVFENDSFLQRVIKTYKKIKKDSAMLLSGCSHLLHNKELMASLAESSFDVMLTDPFLPCSPIVAQYLSLPTVFFLHALPCSLEFEATQCPNPFSYVPRPLSSHSDHMTFLQRVKNMLIAFSQNFLCDVVYSPYATLASEFLQREVTVQDLLSSASVWLFRSDFVKDYPRPIMPNMVFVGGINCLHQNPLSQEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
  
Inhibitor
Name:
BDBM50022178
Synonyms:
4-Methyl-7-hydroxycoumarin | 7-Hydroxy-4-methyl-2H-1-benzopyran-2-one | Imecromone | 7-Hydroxy-4-methyl-2-oxo-2H-1-benzopyran | 7-Hydroxy-4-methyl-2-oxo-3-chromene | beta-Methylumbelliferone | 4-methylumbelliferone | Coumarin derivative, 3b | 7-Hydroxy-4-methylcoumarin | cid_5280567 | CHEMBL12208 | 7-hydroxy-4-methyl-2H-chromen-2-one | 7-Hydroxy-4-methyl-2H-2-one (1)
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: