Target
Acid-sensing ion channel 1
Ligand
BDBM50096642
Substrate
n/a
Meas. Tech.
ChEMBL_1495931 (CHEMBL3579742)
pH
5±n/a
IC50
7340±n/a nM
Comments
extracted
Citation
 Buta, AMaximyuk, OKovalskyy, DSukach, VVovk, MIevglevskyi, OIsaeva, EIsaev, DSavotchenko, AKrishtal, O Novel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction. J Med Chem 58:4449-61 (2015) [PubMed]  Article 
Target
Name:
Acid-sensing ion channel 1
Synonyms:
ACCN2 | ASIC1 | ASIC1_HUMAN | Acid-sensing ion channel 1 | Amiloride-sensitive cation channel 2, neuronal | BNAC2 | Brain sodium channel 2
Type:
PROTEIN
Mol. Mass.:
59900.27
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1495930
Residue:
528
Sequence:
MELKAEEEEVGGVQPVSIQAFASSSTLHGLAHIFSYERLSLKRALWALCFLGSLAVLLCVCTERVQYYFHYHHVTKLDEVAASQLTFPAVTLCNLNEFRFSQVSKNDLYHAGELLALLNNRYEIPDTQMADEKQLEILQDKANFRSFKPKPFNMREFYDRAGHDIRDMLLSCHFRGEVCSAEDFKVVFTRYGKCYTFNSGRDGRPRLKTMKGGTGNGLEIMLDIQQDEYLPVWGETDETSFEAGIKVQIHSQDEPPFIDQLGFGVAPGFQTFVACQEQRLIYLPPPWGTCKAVTMDSDLDFFDSYSITACRIDCETRYLVENCNCRMVHMPGDAPYCTPEQYKECADPALDFLVEKDQEYCVCEMPCNLTRYGKELSMVKIPSKASAKYLAKKFNKSEQYIGENILVLDIFFEVLNYETIEQKKAYEIAGLLGDIGGQMGLFIGASILTVLELFDYAYEVIKHKLCRRGKCQKEAKRSSADKGVALSLDDVKRHNPCESLRGHPAGMTYAANILPHHPARGTFEDFTC
  
Inhibitor
Name:
BDBM50096642
Synonyms:
CHEMBL3577296
Type:
Small organic molecule
Emp. Form.:
C23H27ClN4O2
Mol. Mass.:
426.939
SMILES:
CCN(CC)CCN(Cc1ccc(Cl)cc1)c1ccc2cc(C(N)=N)c(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: