Reaction Details Report a problem with these data
Target
Enoyl-[acyl-carrier-protein] reductase [NADH]
Ligand
BDBM25794
Substrate
n/a
Meas. Tech.
ChEMBL_1460521 (CHEMBL3395431)
IC50
222±n/a nM
Citation
 Rotta, M; Pissinate, K; Villela, AD; Back, DF; Timmers, LF; Bachega, JF; de Souza, ON; Santos, DS; Basso, LA; Machado, P Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies. Eur J Med Chem 90:436-47 (2015) [PubMed]  Article 
Target
Name:
Enoyl-[acyl-carrier-protein] reductase [NADH]
Synonyms:
Enoyl-[acyl-carrier-protein] reductase | NADH-dependent enoyl-ACP reductase | INHA_MYCTU | inhA | Enoyl-[acyl-carrier-protein] reductase [NADH] | Enoyl-ACP Reductase (InhA)
Type:
Enzyme
Mol. Mass.:
28526.00
Organism:
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
Description:
P9WGR1
Residue:
269
Sequence:
MTGLLDGKRILVSGIITDSSIAFHIARVAQEQGAQLVLTGFDRLRLIQRITDRLPAKAPLLELDVQNEEHLASLAGRVTEAIGAGNKLDGVVHSIGFMPQTGMGINPFFDAPYADVSKGIHISAYSYASMAKALLPIMNPGGSIVGMDFDPSRAMPAYNWMTVAKSALESVNRFVAREAGKYGVRSNLVAAGPIRTLAMSAIVGGALGEEAGAQIQLLEEGWDQRAPIGWNMKDATPVAKTVCALLSDWLPATTGDIIYADGGAHTQLL
  
Inhibitor
Name:
BDBM25794
Synonyms:
1-(9H-fluoren-9-yl)-4-[(4-methylphenyl)carbonyl]piperazine | piperazine, p1
Type:
Small organic molecule
Emp. Form.:
C25H24N2O
Mol. Mass.:
368.19
SMILES:
Cc1ccc(cc1)C(=O)N1CCN(CC1)C1c2ccccc2-c2ccccc12
Structure:
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