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Target
Alpha-amylase 1A
Ligand
BDBM50293577
Substrate
n/a
Meas. Tech.
ChEMBL_1516310 (CHEMBL3618750)
IC50
492000±n/a nM
Citation
 Al-Asri, J; Fazekas, E; Lehoczki, G; Perdih, A; Görick, C; Melzig, MF; Gyémánt, G; Wolber, G; Mortier, J From carbohydrates to drug-like fragments: Rational development of novela-amylase inhibitors. Bioorg Med Chem 23:6725-32 (2015) [PubMed]  Article 
Target
Name:
Alpha-amylase 1A
Synonyms:
AMY1A_HUMAN | AMY1A | AMY1 | Alpha-amylase | Salivary alpha-amylase | 1,4-alpha-D-glucan glucanohydrolase 1
Type:
Glycosidase
Mol. Mass.:
57770.18
Organism:
Human
Description:
Purchased from Sigma Chemical Co.
Residue:
511
Sequence:
MKLFWLLFTIGFCWAQYSSNTQQGRTSIVHLFEWRWVDIALECERYLAPKGFGGVQVSPPNENVAIHNPFRPWWERYQPVSYKLCTRSGNEDEFRNMVTRCNNVGVRIYVDAVINHMCGNAVSAGTSSTCGSYFNPGSRDFPAVPYSGWDFNDGKCKTGSGDIENYNDATQVRDCRLSGLLDLALGKDYVRSKIAEYMNHLIDIGVAGFRIDASKHMWPGDIKAILDKLHNLNSNWFPEGSKPFIYQEVIDLGGEPIKSSDYFGNGRVTEFKYGAKLGTVIRKWNGEKMSYLKNWGEGWGFMPSDRALVFVDNHDNQRGHGAGGASILTFWDARLYKMAVGFMLAHPYGFTRVMSSYRWPRYFENGKDVNDWVGPPNDNGVTKEVTINPDTTCGNDWVCEHRWRQIRNMVNFRNVVDGQPFTNWYDNGSNQVAFGRGNRGFIVFNNDDWTFSLTLQTGLPAGTYCDVISGDKINGNCTGIKIYVSDDGKAHFSISNSAEDPFIAIHAESKL
  
Inhibitor
Name:
BDBM50293577
Synonyms:
cid_972292 | CHEMBL563294 | 4-(4-(4-Hydroxyphenyl)thiazol-2-ylamino)phenol
Type:
Small organic molecule
Emp. Form.:
C15 H12 N2 O2 S
Mol. Mass.:
284.33298
SMILES:
Oc1ccc(Nc2nc(cs2)-c2ccc(O)cc2)cc1
Structure:
Search PDB for entries with ligand similarity: