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Target
Reduced folate transporter
Ligand
BDBM50126174
Substrate
n/a
Meas. Tech.
ChEMBL_1523799 (CHEMBL3632250)
IC50
189±n/a nM
Citation
 Wang, L; Wallace, A; Raghavan, S; Deis, SM; Wilson, MR; Yang, S; Polin, L; White, K; Kushner, J; Orr, S; George, C; O'Connor, C; Hou, Z; Mitchell-Ryan, S; Dann, CE; Matherly, LH; Gangjee, A 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptora and the Proton-Coupled Folate Transporter in Human Tumors. J Med Chem 58:6938-59 (2015) [PubMed]  Article 
Target
Name:
Reduced folate transporter
Synonyms:
FOLT | IFC-1 | Intestinal folate carrier | Placental folate transporter | RFC | Reduced folate carrier protein | Solute carrier family 19 member 1 | S19A1_HUMAN | SLC19A1 | FLOT1 | RFC1 | Folate transporter 1
Type:
PROTEIN
Mol. Mass.:
64885.16
Organism:
Human
Description:
ChEMBL_1469594
Residue:
591
Sequence:
MVPSSPAVEKQVPVEPGPDPELRSWRHLVCYLCFYGFMAQIRPGESFITPYLLGPDKNFTREQVTNEITPVLSYSYLAVLVPVFLLTDYLRYTPVLLLQGLSFVSVWLLLLLGHSVAHMQLMELFYSVTMAARIAYSSYIFSLVRPARYQRVAGYSRAAVLLGVFTSSVLGQLLVTVGRVSFSTLNYISLAFLTFSVVLALFLKRPKRSLFFNRDDRGRCETSASELERMNPGPGGKLGHALRVACGDSVLARMLRELGDSLRRPQLRLWSLWWVFNSAGYYLVVYYVHILWNEVDPTTNSARVYNGAADAASTLLGAITSFAAGFVKIRWARWSKLLIAGVTATQAGLVFLLAHTRHPSSIWLCYAAFVLFRGSYQFLVPIATFQIASSLSKELCALVFGVNTFFATIVKTIITFIVSDVRGLGLPVRKQFQLYSVYFLILSIIYFLGAMLDGLRHCQRGHHPRQPPAQGLRSAAEEKAAQALSVQDKGLGGLQPAQSPPLSPEDSLGAVGPASLEQRQSDPYLAQAPAPQAAEFLSPVTTPSPCTLCSAQASGPEAADETCPQLAVHPPGVSKLGLQCLPSDGVQNVNQ
  
Inhibitor
Name:
BDBM50126174
Synonyms:
CHEMBL3628346
Type:
Small organic molecule
Emp. Form.:
C19H21N5O6S
Mol. Mass.:
447.12
SMILES:
c1c(csc1CCCc2cc3c([nH]2)N=C(NC3=O)N)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Structure:
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