Reaction Details Report a problem with these data
Target
Aromatase
Ligand
BDBM50398447
Substrate
n/a
Meas. Tech.
ChEMBL_1547308 (CHEMBL3756944)
IC50
230±n/a nM
Citation
 Yadav, MR; Barmade, MA; Tamboli, RS; Murumkar, PR Developing steroidal aromatase inhibitors-an effective armament to win the battle against breast cancer. Eur J Med Chem 105:1-38 (2015) [PubMed]  Article 
Target
Name:
Aromatase
Synonyms:
Aromatase | CYPXIX | Cytochrome P-450AROM | Cytochrome P450 2C19 | Cytochrome P450-C19 (CYP19) | Estrogen synthetase | FL cytokine receptor precursor | P-450AROM | CP19A_HUMAN | CYP19A1 | ARO1 | CYAR | CYP19 | Cytochrome P450 19A1
Type:
Enzyme
Mol. Mass.:
57888.92
Organism:
Human
Description:
P11511
Residue:
503
Sequence:
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
  
Inhibitor
Name:
BDBM50398447
Synonyms:
Aromasin | EXEMESTANE
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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