Reaction Details Report a problem with these data
Target
L-lactate dehydrogenase B chain
Ligand
BDBM50066978
Substrate
n/a
Meas. Tech.
ChEMBL_1555231 (CHEMBL3768757)
Ki
250000±n/a nM
Citation
 Rani, R; Kumar, V Recent Update on Human Lactate Dehydrogenase Enzyme 5 (hLDH5) Inhibitors: A Promising Approach for Cancer Chemotherapy. J Med Chem 59:487-96 (2016) [PubMed]  Article 
Target
Name:
L-lactate dehydrogenase B chain
Synonyms:
LDH-H | L-lactate dehydrogenase B | LDH heart subunit | LDH-B | Renal carcinoma antigen NY-REN-46 | LDHB_HUMAN | LDHB | L-lactate dehydrogenase B chain | Lactate dehydrogenase B (LDHB)
Type:
Oxidoreductase; homotetramer
Mol. Mass.:
36635.55
Organism:
Human
Description:
n/a
Residue:
334
Sequence:
MATLKEKLIAPVAEEEATVPNNKITVVGVGQVGMACAISILGKSLADELALVDVLEDKLKGEMMDLQHGSLFLQTPKIVADKDYSVTANSKIVVVTAGVRQQEGESRLNLVQRNVNVFKFIIPQIVKYSPDCIIIVVSNPVDILTYVTWKLSGLPKHRVIGSGCNLDSARFRYLMAEKLGIHPSSCHGWILGEHGDSSVAVWSGVNVAGVSLQELNPEMGTDNDSENWKEVHKMVVESAYEVIKLKGYTNWAIGLSVADLIESMLKNLSRIHPVSTMVKGMYGIENEVFLSLPCILNARGLTSVINQKLKDDEVAQLKKSADTLWDIQKDLKDL
  
Inhibitor
Name:
BDBM50066978
Synonyms:
2,3-Dihydroxy-4,6-dimethyl-naphthalene-1-carboxylic acid | CHEMBL127645
Type:
Small organic molecule
Emp. Form.:
n/a
Mol. Mass.:
n/a
SMILES:
Cc1ccc2c(C(O)=O)c(O)c(O)c(C)c2c1
Structure:
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