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Target
Ephrin type-B receptor 4
Ligand
BDBM50154564
Substrate
n/a
Meas. Tech.
ChEMBL_1561200 (CHEMBL3777628)
IC50
300±n/a nM
Citation
 Unzue, A; Lafleur, K; Zhao, H; Zhou, T; Dong, J; Kolb, P; Liebl, J; Zahler, S; Caflisch, A; Nevado, C Three stories on Eph kinase inhibitors: From in silico discovery to in vivo validation. Eur J Med Chem 112:347-66 (2016) [PubMed]  Article 
Target
Name:
Ephrin type-B receptor 4
Synonyms:
Tyrosine-protein kinase TYRO11 | Ephrin type-B receptor 4 precursor (Tyrosine-protein kinase receptor HTK). | Hepatoma transmembrane kinase | EPHB4_HUMAN | EPHB4 | HTK | MYK1 | TYRO11 | VHL/Ephrin type-B receptor 4 | Ephrin receptor
Type:
Enzyme
Mol. Mass.:
108273.51
Organism:
Human
Description:
P54760
Residue:
987
Sequence:
MELRVLLCWASLAAALEETLLNTKLETADLKWVTFPQVDGQWEELSGLDEEQHSVRTYEVCDVQRAPGQAHWLRTGWVPRRGAVHVYATLRFTMLECLSLPRAGRSCKETFTVFYYESDADTATALTPAWMENPYIKVDTVAAEHLTRKRPGAEATGKVNVKTLRLGPLSKAGFYLAFQDQGACMALLSLHLFYKKCAQLTVNLTRFPETVPRELVVPVAGSCVVDAVPAPGPSPSLYCREDGQWAEQPVTGCSCAPGFEAAEGNTKCRACAQGTFKPLSGEGSCQPCPANSHSNTIGSAVCQCRVGYFRARTDPRGAPCTTPPSAPRSVVSRLNGSSLHLEWSAPLESGGREDLTYALRCRECRPGGSCAPCGGDLTFDPGPRDLVEPWVVVRGLRPDFTYTFEVTALNGVSSLATGPVPFEPVNVTTDREVPPAVSDIRVTRSSPSSLSLAWAVPRAPSGAVLDYEVKYHEKGAEGPSSVRFLKTSENRAELRGLKRGASYLVQVRARSEAGYGPFGQEHHSQTQLDESEGWREQLALIAGTAVVGVVLVLVVIVVAVLCLRKQSNGREAEYSDKHGQYLIGHGTKVYIDPFTYEDPNEAVREFAKEIDVSYVKIEEVIGAGEFGEVCRGRLKAPGKKESCVAIKTLKGGYTERQRREFLSEASIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLNDGQFTVIQLVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSSDPTYTSSLGGKIPIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSALDKMIRNPASLKIVARENGGASHPLLDQRQPHYSAFGSVGEWLRAIKMGRYEESFAAAGFGSFELVSQISAEDLLRIGVTLAGHQKKILASVQHMKSQAKPGTPGGTGGPAPQY
  
Inhibitor
Name:
BDBM50154564
Synonyms:
CHEMBL3774835 | US10688093, Compound DT2012-0375412 | US11701353, Compound DT2012-0375412
Type:
Small organic molecule
Emp. Form.:
C18H15N5O2
Mol. Mass.:
333.12
SMILES:
COc1cccc(c1)-n1c(N)c(C(N)=O)c2nc3ccccc3nc12
Structure:
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