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Target
Serine/threonine-protein kinase 17B
Ligand
BDBM7392
Substrate
n/a
Meas. Tech.
ChEMBL_1575376 (CHEMBL3802094)
IC50
>10000±n/a nM
Citation
 Jung, ME; Byun, BJ; Kim, HM; Lee, JY; Park, JH; Lee, N; Son, YH; Choi, SU; Yang, KM; Kim, SJ; Lee, K; Kim, YC; Choi, G Discovery of indirubin derivatives as new class of DRAK2 inhibitors from high throughput screening. Bioorg Med Chem Lett 26:2719-23 (2016) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 17B
Synonyms:
ST17B_HUMAN | STK17B | DRAK2 | Serine/threonine-protein kinase 17B (STK17B)
Type:
Enzyme
Mol. Mass.:
42332.49
Organism:
Human
Description:
O94768
Residue:
372
Sequence:
MSRRRFDCRSISGLLTTTPQIPIKMENFNNFYILTSKELGRGKFAVVRQCISKSTGQEYAAKFLKKRRRGQDCRAEILHEIAVLELAKSCPRVINLHEVYENTSEIILILEYAAGGEIFSLCLPELAEMVSENDVIRLIKQILEGVYYLHQNNIVHLDLKPQNILLSSIYPLGDIKIVDFGMSRKIGHACELREIMGTPEYLAPEILNYDPITTATDMWNIGIIAYMLLTHTSPFVGEDNQETYLNISQVNVDYSEETFSSVSQLATDFIQSLLVKNPEKRPTAEICLSHSWLQQWDFENLFHPEETSSSSQTQDHSVRSSEDKTSKSSCNGTCGDREDKENIPEDSSMVSKRFRFDDSLPNPHELVSDLLC
  
Inhibitor
Name:
BDBM7392
Synonyms:
2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one | cid_5318433 | Indirubin derivative, 1 | Indirubin
Type:
Small organic molecule
Emp. Form.:
C16H10N2O2
Mol. Mass.:
262.07
SMILES:
c1ccc2c(c1)/C(=C/3\C(=O)c4ccccc4N3)/C(=O)N2
Structure:
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