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Target
Thymidine phosphorylase
Ligand
BDBM50019242
Substrate
n/a
Meas. Tech.
ChEMBL_1576854 (CHEMBL3806498)
IC50
42900±n/a nM
Citation
 Khan, I; Zaib, S; Batool, S; Abbas, N; Ashraf, Z; Iqbal, J; Saeed, A Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification. Bioorg Med Chem 24:2361-81 (2016) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TdRPase | TYPH_ECOLI | deoA | tpp | ttg | Thymidine Phosphorylase (TP)
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50019242
Synonyms:
CHEMBL3289117 | 2-(3',4'-Dihydroxyphenyl)quinazolin-4(3H)-one (5)
Type:
Small organic molecule
Emp. Form.:
C14H10N2O3
Mol. Mass.:
254.07
SMILES:
Oc1ccc(cc1O)-c1nc2ccccc2c(=O)[nH]1
Structure:
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