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Target
Thymidine phosphorylase
Ligand
BDBM50170996
Substrate
n/a
Meas. Tech.
ChEMBL_1576854 (CHEMBL3806498)
IC50
41000±n/a nM
Citation
 Khan, I; Zaib, S; Batool, S; Abbas, N; Ashraf, Z; Iqbal, J; Saeed, A Quinazolines and quinazolinones as ubiquitous structural fragments in medicinal chemistry: An update on the development of synthetic methods and pharmacological diversification. Bioorg Med Chem 24:2361-81 (2016) [PubMed]  Article 
Target
Name:
Thymidine phosphorylase
Synonyms:
TdRPase | TYPH_ECOLI | deoA | tpp | ttg | Thymidine Phosphorylase (TP)
Type:
Enzyme
Mol. Mass.:
47198.54
Organism:
Escherichia coli (strain K12)
Description:
n/a
Residue:
440
Sequence:
MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLTMAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHTGGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSIPLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLTDMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKLQAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALGMAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENNWQEAAKAVKAAIKLADKAPESTPTVYRRISE
  
Inhibitor
Name:
BDBM50170996
Synonyms:
CHEMBL501902
Type:
Small organic molecule
Emp. Form.:
C6H3N3O2
Mol. Mass.:
149.02
SMILES:
O=C1NC(=O)C2=CC=NC2=N1 |c:7,10,t:5|
Structure:
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