Reaction Details Report a problem with these data
Target
Caspase-5
Ligand
BDBM50200546
Substrate
n/a
Meas. Tech.
ChEMBL_1622627 (CHEMBL3864979)
Ki
111±n/a nM
Citation
 Kent, CR; Bryja, M; Gustafson, HA; Kawarski, MY; Lenti, G; Pierce, EN; Knopp, RC; Ceja, V; Pati, B; Walters, DE; Karver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett 26:5476-5480 (2016) [PubMed]  Article 
Target
Name:
Caspase-5
Synonyms:
Caspase-5 subunit p10 | Caspase-5 subunit p20 | ICE(rel)-III | TY protease | ICH-3 protease | Protease ICH-3 | CASP-5 | Caspase 5 | Protease TY | CASP5_HUMAN | CASP5 | ICH3
Type:
Enzyme
Mol. Mass.:
49760.80
Organism:
Human
Description:
P51878
Residue:
434
Sequence:
MAEDSGKKKRRKNFEAMFKGILQSGLDNFVINHMLKNNVAGQTSIQTLVPNTDQKSTSVKKDNHKKKTVKMLEYLGKDVLHGVFNYLAKHDVLTLKEEEKKKYYDTKIEDKALILVDSLRKNRVAHQMFTQTLLNMDQKITSVKPLLQIEAGPPESAESTNILKLCPREEFLRLCKKNHDEIYPIKKREDRRRLALIICNTKFDHLPARNGAHYDIVGMKRLLQGLGYTVVDEKNLTARDMESVLRAFAARPEHKSSDSTFLVLMSHGILEGICGTAHKKKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGEKHGELWVRDSPASLALISSQSSENLEADSVCKIHEEKDFIAFCSSTPHNVSWRDRTRGSIFITELITCFQKYSCCCHLMEIFRKVQKSFEVPQAKAQMPTIERATLTRDFYLFPGN
  
Inhibitor
Name:
BDBM50200546
Synonyms:
CHEMBL3939229
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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