Reaction Details Report a problem with these data
Target
Caspase-4
Ligand
BDBM50200546
Substrate
n/a
Meas. Tech.
ChEMBL_1622626 (CHEMBL3864978)
IC50
746±n/a nM
Citation
 Kent, CR; Bryja, M; Gustafson, HA; Kawarski, MY; Lenti, G; Pierce, EN; Knopp, RC; Ceja, V; Pati, B; Walters, DE; Karver, CE Variation of the aryl substituent on the piperazine ring within the 4-(piperazin-1-yl)-2,6-di(pyrrolidin-1-yl)pyrimidine scaffold unveils potent, non-competitive inhibitors of the inflammatory caspases. Bioorg Med Chem Lett 26:5476-5480 (2016) [PubMed]  Article 
Target
Name:
Caspase-4
Synonyms:
Caspase-4 subunit 2 | Caspase-4 subunit 1 | ICE(rel)-II | TX protease | CASP-4 | ICH-2 protease | Caspase 4 | CASP4_HUMAN | CASP4 | ICH2
Type:
Enzyme
Mol. Mass.:
43257.75
Organism:
Human
Description:
P49662
Residue:
377
Sequence:
MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN
  
Inhibitor
Name:
BDBM50200546
Synonyms:
CHEMBL3939229
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: