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Target
Alpha-galactosidase A
Ligand
BDBM50099009
Substrate
n/a
Meas. Tech.
ChEMBL_1627784 (CHEMBL3870369)
pH
4.6000±n/a
IC50
670±n/a nM
Comments
extracted
Citation
 Cheng, WC; Wang, JH; Li, HY; Lu, SJ; Hu, JM; Yun, WY; Chiu, CH; Yang, WB; Chien, YH; Hwu, WL Bioevaluation of sixteen ADMDP stereoisomers toward alpha-galactosidase A: Development of a new pharmacological chaperone for the treatment of Fabry disease and potential enhancement of enzyme replacement therapy efficiency. Eur J Med Chem 123:14-20 (2016) [PubMed]  Article 
Target
Name:
Alpha-galactosidase A
Synonyms:
INN=Agalsidase | Melibiase | Alpha-D-galactosidase A | Alpha-D-galactoside galactohydrolase | AGAL_HUMAN | GLA | Alpha-galactosidase A | Alpha-glucosidase A (α-Gal A)
Type:
Protein
Mol. Mass.:
48760.21
Organism:
Human
Description:
n/a
Residue:
429
Sequence:
MQLRNPELHLGCALALRFLALVSWDIPGARALDNGLARTPTMGWLHWERFMCNLDCQEEPDSCISEKLFMEMAELMVSEGWKDAGYEYLCIDDCWMAPQRDSEGRLQADPQRFPHGIRQLANYVHSKGLKLGIYADVGNKTCAGFPGSFGYYDIDAQTFADWGVDLLKFDGCYCDSLENLADGYKHMSLALNRTGRSIVYSCEWPLYMWPFQKPNYTEIRQYCNHWRNFADIDDSWKSIKSILDWTSFNQERIVDVAGPGGWNDPDMLVIGNFGLSWNQQVTQMALWAIMAAPLFMSNDLRHISPQAKALLQDKDVIAINQDPLGKQGYQLRQGDNFEVWERPLSGLAWAVAMINRQEIGGPRSYTIAVASLGKGVACNPACFITQLLPVKRKLGFYEWTSRLRSHINPTGTVLLQLENTMQMSLKDLL
  
Inhibitor
Name:
BDBM50099009
Synonyms:
CHEMBL3350086 | BDBM50204612 | (3S,4S,5R)-2-Aminomethyl-5-hydroxymethyl-pyrrolidine-3,4-diol
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
Search PDB for entries with ligand similarity: