Reaction Details Report a problem with these data
Target
Eukaryotic initiation factor 4A-II
Ligand
BDBM50235738
Substrate
n/a
Meas. Tech.
ChEMBL_1657828 (CHEMBL4007298)
IC50
18000±n/a nM
Citation
 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem 25:2200-2209 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-II
Synonyms:
ATP-dependent RNA helicase eIF4A-2 | eIF-4A-II | eIF4A-II | IF4A2_HUMAN | EIF4A2 | DDX2B | EIF4F
Type:
Protein
Mol. Mass.:
46394.69
Organism:
Human
Description:
Q14240
Residue:
407
Sequence:
MSGGSADYNREHGGPEGMDPDGVIESNWNEIVDNFDDMNLKESLLRGIYAYGFEKPSAIQQRAIIPCIKGYDVIAQAQSGTGKTATFAISILQQLEIEFKETQALVLAPTRELAQQIQKVILALGDYMGATCHACIGGTNVRNEMQKLQAEAPHIVVGTPGRVFDMLNRRYLSPKWIKMFVLDEADEMLSRGFKDQIYEIFQKLNTSIQVVLLSATMPTDVLEVTKKFMRDPIRILVKKEELTLEGIKQFYINVEREEWKLDTLCDLYETLTITQAVIFLNTRRKVDWLTEKMHARDFTVSALHGDMDQKERDVIMREFRSGSSRVLITTDLLARGIDVQQVSLVINYDLPTNRENYIHRIGRGGRFGRKGVAINFVTEEDKRILRDIETFYNTTVEEMPMNVADLI
  
Inhibitor
Name:
BDBM50235738
Synonyms:
Hippuristanol
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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