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Target
Eukaryotic initiation factor 4A-III
Ligand
BDBM50235738
Substrate
n/a
Meas. Tech.
ChEMBL_1657827 (CHEMBL4007297)
IC50
40000±n/a nM
Citation
 Ito, M; Iwatani, M; Kamada, Y; Sogabe, S; Nakao, S; Tanaka, T; Kawamoto, T; Aparicio, S; Nakanishi, A; Imaeda, Y Discovery of selective ATP-competitive eIF4A3 inhibitors. Bioorg Med Chem 25:2200-2209 (2017) [PubMed]  Article 
Target
Name:
Eukaryotic initiation factor 4A-III
Synonyms:
ATP-dependent RNA helicase DDX48 | ATP-dependent RNA helicase eIF4A-3 | DEAD box protein 48 | Eukaryotic initiation factor 4A-like NUK-34 | Eukaryotic translation initiation factor 4A isoform 3 | Nuclear matrix protein 265 | eIF-4A-III | eIF4A-III | NMP 265 | hNMP 265 | IF4A3_HUMAN | EIF4A3 | DDX48 | KIAA0111
Type:
Protein
Mol. Mass.:
46871.02
Organism:
Human
Description:
P38919
Residue:
411
Sequence:
MATTATMATSGSARKRLLKEEDMTKVEFETSEEVDVTPTFDTMGLREDLLRGIYAYGFEKPSAIQQRAIKQIIKGRDVIAQSQSGTGKTATFSISVLQCLDIQVRETQALILAPTRELAVQIQKGLLALGDYMNVQCHACIGGTNVGEDIRKLDYGQHVVAGTPGRVFDMIRRRSLRTRAIKMLVLDEADEMLNKGFKEQIYDVYRYLPPATQVVLISATLPHEILEMTNKFMTDPIRILVKRDELTLEGIKQFFVAVEREEWKFDTLCDLYDTLTITQAVIFCNTKRKVDWLTEKMREANFTVSSMHGDMPQKERESIMKEFRSGASRVLISTDVWARGLDVPQVSLIINYDLPNNRELYIHRIGRSGRYGRKGVAINFVKNDDIRILRDIEQYYSTQIDEMPMNVADLI
  
Inhibitor
Name:
BDBM50235738
Synonyms:
Hippuristanol
Type:
Small organic molecule
Emp. Form.:
TBD
Mol. Mass.:
TBD
SMILES:
TBD
Structure:
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